Pb Toxicity on Gut Physiology and Microbiota.
Pb Toxicity on Gut Physiology and Microbiota.
复制标题
铅对肠道生理和微生物的毒性
DOI：
10.3389/fphys.2021.574913
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发表时间：
2021
影响因子：
4
通讯作者：
Yang F
中科院分区：
文献类型：
--
作者：
Liu W;Feng H;Zheng S;Xu S;Massey IY;Zhang C;Wang X;Yang F
铅（Pb）是一种有毒的重金属，对全球人口有着深远的威胁。肾脏、肝脏、神经系统、血液系统和生殖系统等多个器官通常被认为是铅毒性的靶器官。越来越多的研究报道铅对胃肠道的影响同样强烈，尤其是对肠道菌群的影响。本文综述了铅对不同动物模型和人体肠道生理和微生物区系的毒性作用，这些毒性作用的改变可能进一步影响宿主的其他器官。更具体地说，铅可损害肠道屏障，增加肠道通透性，使炎症细胞因子、免疫因子以及胆汁酸（BA）、短链脂肪酸（SCFAs）等微生物代谢产物更容易进入肠肝循环，最终导致多系统损害。此外，我们强调，益生菌治疗可能是一个可行的和有效的策略，以防止铅中毒。
Lead (Pb) is a toxic heavy metal, having profound threats to the global population. Multiple organs such as kidney, and liver, as well as nervous, hematologic, and reproductive systems, are commonly considered the targets of Pb toxicity. Increasing researches reported that the effects of Pb on gastrointestinal tracts are equally intensive, especially on intestinal microbiota. This review summarized Pb toxicity on gut physiology and microbiota in different animal models and in humans, of which the alterations may further have effects on other organs in host. To be more specific, Pb can impair gut barrier and increase gut permeability, which make inflammatory cytokines, immunologic factors, as well as microbial metabolites such as bile acids (BA) and short-chain fatty acids (SCFAs) enter the enterohepatic circulation easily, and finally induce multiple systematic lesion. In addition, we emphasized that probiotic treatment may be one of the feasible and effective strategies for preventing Pb toxicity.
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影响因子：
8.3
作者：
Clark, Heather F.;Hausladen, Debra M.;Brabander, Daniel J.
通讯作者：
Brabander, Daniel J.
影响因子：
7.7
作者：
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通讯作者：
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影响因子：
11.2
作者：
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通讯作者：
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影响因子：
6.4
作者：
Bisanz JE;Enos MK;Mwanga JR;Changalucha J;Burton JP;Gloor GB;Reid G
通讯作者：
Reid G
DOI：
10.1186/s12940-015-0008-9
发表时间：
2015-04-07
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
Evens A;Hryhorczuk D;Lanphear BP;Rankin KM;Lewis DA;Forst L;Rosenberg D
通讯作者：
Rosenberg D