CD46 processing: a means of expression.
CD46 processing: a means of expression.
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DOI：
10.1016/j.imbio.2011.06.003
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发表时间：
2012-02
期刊：
影响因子：
2.8
通讯作者：
Astier, Anne L.
中科院分区：
文献类型：
--
作者：
Ni Choileain, Siobhan;Astier, Anne L.
CD46是一种普遍表达的I型跨膜蛋白，最初被认为是补体激活的调节剂，后来被认为是多种病原体的进入受体。过去十年也揭示了CD46在调节适应性免疫反应中的作用，作为人类T细胞的额外共刺激分子并诱导其分化为Tr1细胞，Tr1细胞是调节性T细胞的一个亚群。有趣的是，CD46调控通路在多发性硬化症、哮喘和类风湿关节炎患者的T细胞中存在缺陷，说明其在调节T细胞稳态中的重要性。事实上，在许多不同的细胞类型中，细胞表面的CD46表达受到严格调控，这突出了它在几个生物过程中的重要性。值得注意的是，CD46是酶加工的靶标，可被金属蛋白酶和早老素/ γ分泌酶切割。至少在T细胞中，这种处理是其功能所必需的。本文将对CD46表达调控及其对T细胞活化作用的最新研究进展进行综述。
CD46 is a ubiquitously expressed type I transmembrane protein, first identified as a regulator of complement activation, and later as an entry receptor for a variety of pathogens. The last decade has also revealed the role of CD46 in regulating the adaptive immune response, acting as an additional costimulatory molecule for human T cells and inducing their differentiation into Tr1 cells, a subset of regulatory T cells. Interestingly, CD46 regulatory pathways are defective in T cells from patients with multiple sclerosis, asthma and rheumatoid arthritis, illustrating its importance in regulating T cell homeostasis. Indeed, CD46 expression at the cell surface is tightly regulated in many different cell types, highlighting its importance in several biological processes. Notably, CD46 is the target of enzymatic processing, being cleaved by metalloproteinases and by the presenilin/gamma secretase. This processing is required for its functions, at least in T cells. This review will summarize the latest updates on the regulation of CD46 expression and on its effects on T cell activation.
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DOI：
10.1084/jem.20031159
发表时间：
2003-11-03
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Gill DB;Koomey M;Cannon JG;Atkinson JP
通讯作者：
Atkinson JP
影响因子：
3.2
作者：
Berti, R;Brennan, MB;Jacobson, S
通讯作者：
Jacobson, S
影响因子：
3.6
作者：
Cole, Duncan S.;Hughes, Timothy R.;Morgan, B. Paul
通讯作者：
Morgan, B. Paul
影响因子：
13.6
作者：
Fremeaux-Bacchi, Veronique;Moulton, Elizabeth A.;Atkinson, John P.
通讯作者：
Atkinson, John P.
影响因子：
6.4
作者：
Cermelli, C;Berti, R;Jacobson, S
通讯作者：
Jacobson, S