Voxelwise lp-ntPET for detecting localized, transient dopamine release of unknown timing: sensitivity analysis and application to cigarette smoking in the PET scanner.
Voxelwise lp-ntPET for detecting localized, transient dopamine release of unknown timing: sensitivity analysis and application to cigarette smoking in the PET scanner.
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DOI：
10.1002/hbm.22519
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发表时间：
2014-09
影响因子：
4.8
通讯作者：
Morris, Evan D.
中科院分区：
文献类型：
--
作者：
Kim, Su Jin;Sullivan, Jenna M.;Wang, Shuo;Cosgrove, Kelly P.;Morris, Evan D.
“线性参数神经递质 PET”（lp-ntPET）模型根据动态 PET 数据估计内源性神经递质水平的时间变化。多巴胺（DA）随时间变化的模式可能是大脑对香烟或酒精等成瘾物质做出反应的一个重要因素。我们将 lp-ntPET 模型从基于原始感兴趣区域 (ROI) 的实现扩展为能够在体素级别应用该模型。由此产生的终点是短暂神经递质变化的动态图像或电影。进行模拟以选择阈值，以降低应用于真实 11C-雷氯必利 PET 数据时的假阳性率。我们在模拟数据上测试了新的体素方法，最后，我们将其应用于 PET 扫描仪中吸烟受试者的 11C-雷氯必利 PET 数据。在模拟中，神经递质响应的时间精度与基于 ROI 的 lp-ntPET 相似（标准差 ~ 3 分钟）。通过将统计阈值（F 检验）与新的空间（簇大小）阈值操作相结合，可以很好地控制体素方法的假阳性率。对于纹状体子区域中发生的短暂 DA 变化（如吸烟的情况），新算法的检测灵敏度大于 80%。最后，在 11C-雷氯必利 PET 数据中，DA 电影首次揭示了纹状体不同分区中可能存在 DA 对吸烟反应的不同时间模式。这些由体素 lp-ntPET 产生的神经递质变化的时空模式可以作为成瘾和/或治疗效果的新型生物标志物。 Hum Brain Mapp 35:4876–4891, 2014。© 2014 作者。人脑图谱由 Wiley periodicals, Inc. 出版
The “linear parametric neurotransmitter PET” (lp‐ntPET) model estimates time variation in endogenous neurotransmitter levels from dynamic PET data. The pattern of dopamine (DA) change over time may be an important element of the brain's response to addictive substances such as cigarettes or alcohol. We have extended the lp‐ntPET model from the original region of interest (ROI) ‐ based implementation to be able to apply the model at the voxel level. The resulting endpoint is a dynamic image, or movie, of transient neurotransmitter changes. Simulations were performed to select threshold values to reduce the false positive rate when applied to real 11C‐raclopride PET data. We tested the new voxelwise method on simulated data, and finally, we applied it to 11C‐raclopride PET data of subjects smoking cigarettes in the PET scanner. In simulation, the temporal precision of neurotransmitter response was shown to be similar to that of ROI‐based lp‐ntPET (standard deviation ∼ 3 min). False positive rates for the voxelwise method were well controlled by combining a statistical threshold (the F‐test) with a new spatial (cluster‐size) thresholding operation. Sensitivity of detection for the new algorithm was greater than 80% for the case of short‐lived DA changes that occur in subregions of the striatum as might be the case with cigarette smoking. Finally, in 11C‐raclopride PET data, DA movies reveal for the first time that different temporal patterns of the DA response to smoking may exist in different subregions of the striatum. These spatiotemporal patterns of neurotransmitter change created by voxelwise lp‐ntPET may serve as novel biomarkers for addiction and/or treatment efficacy. Hum Brain Mapp 35:4876–4891, 2014. © 2014 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc.
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影响因子：
3.1
作者：
Morris, Evan D.;Normandin, Marc D.;Schiffer, Wynne K.
通讯作者：
Schiffer, Wynne K.
影响因子：
5.7
作者：
Gunn, RN;Lammertsma, AA;Cunningham, VJ
通讯作者：
Cunningham, VJ
影响因子：
6.6
作者：
Lataster, Johan;Collip, Dina;Myin-Germeys, Inez
通讯作者：
Myin-Germeys, Inez
DOI：
10.3791/50358
发表时间：
2013-08-06
期刊：
Journal of visualized experiments : JoVE
影响因子：
--
作者：
Morris ED;Kim SJ;Sullivan JM;Wang S;Normandin MD;Constantinescu CC;Cosgrove KP
通讯作者：
Cosgrove KP
影响因子：
5.7
作者：
Lammertsma, AA;Hume, SP
通讯作者：
Hume, SP