Genome-wide association study of Arabidopsis thaliana leaf microbial community.
Genome-wide association study of Arabidopsis thaliana leaf microbial community.
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DOI：
10.1038/ncomms6320
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发表时间：
2014-11-10
影响因子：
16.6
通讯作者：
Bergelson, Joy
中科院分区：
文献类型：
--
作者：
Horton, Matthew W.;Bodenhausen, Natacha;Beilsmith, Kathleen;Meng, Dazhe;Muegge, Brian D.;Subramanian, Sathish;Vetter, M. Madlen;Vilhjalmsson, Bjarni J.;Nordborg, Magnus;Gordon, Jeffrey I.;Bergelson, Joy
确定影响宿主-微生物相互作用结果的因素对于保护生物多样性、最大限度地减少农业损失和改善人类健康至关重要。在模式物种中已经确定了几个决定共生或对传染病抵抗力的基因，但缺乏关于宿主的基因型如何影响其微生物群落结构的全面检查。在这里，我们报告了模式植物拟南芥的田间实验结果，以确定寄生在其叶片上的真菌和细菌，以及影响微生物数量的寄主位置。该群落的组成因刺参种质的不同而不同。全基因组关联研究表明，负责防御和细胞壁完整性的植物基因座影响该群落的变异。此外，细菌群落中的物种丰富度是由宿主遗传变异决定的，特别是在也影响病毒复制、毛状体分枝和形态发生的基因座上。
Identifying the factors that influence the outcome of host-microbial interactions is critical to protecting biodiversity, minimizing agricultural losses, and improving human health. A few genes that determine symbiosis or resistance to infectious disease have been identified in model species, but a comprehensive examination of how a host's genotype influences the structure of its microbial community is lacking. Here we report the results of a field experiment with the model plant Arabidopsis thaliana to identify the fungi and bacteria that colonize its leaves and the host loci that influence the microbes’ numbers. The composition of this community differs among accessions of A. thaliana. Genome-wide association studies (GWAS) suggest that plant loci responsible for defense and cell wall integrity affect variation in this community. Furthermore, species richness in the bacterial community is shaped by host genetic variation, notably at loci that also influence the reproduction of viruses, trichome branching and morphogenesis.
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影响因子：
5.8
作者：
Horton, Matthew;Bodenhausen, Natacha;Bergelson, Joy
通讯作者：
Bergelson, Joy
DOI：
10.1073/pnas.0807920105
发表时间：
2008-11-18
影响因子：
11.1
作者：
Fierer, Noah;Hamady, Micah;Knight, Rob
通讯作者：
Knight, Rob
影响因子：
3.5
作者：
Balint-Kurti, Peter;Simmons, Susan J.;Stapleton, Ann E.
通讯作者：
Stapleton, Ann E.
影响因子：
7.2
作者：
Hardham, Adrienne R.
通讯作者：
Hardham, Adrienne R.
影响因子：
4.5
作者：
Brachi B;Faure N;Horton M;Flahauw E;Vazquez A;Nordborg M;Bergelson J;Cuguen J;Roux F
通讯作者：
Roux F