The Near-Road Exposures and Effects of Urban Air Pollutants Study (NEXUS): study design and methods.
The Near-Road Exposures and Effects of Urban Air Pollutants Study (NEXUS): study design and methods.
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DOI：
10.1016/j.scitotenv.2012.10.072
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发表时间：
2013-03-15
期刊：
影响因子：
--
通讯作者：
Community Action Against Asthma Steering Committee
中科院分区：
文献类型：
--
作者：
Vette A;Burke J;Norris G;Landis M;Batterman S;Breen M;Isakov V;Lewis T;Gilmour MI;Kamal A;Hammond D;Vedantham R;Bereznicki S;Tian N;Croghan C;Community Action Against Asthma Steering Committee
城市空气污染物的近道路暴露和影响研究（NEXUS）旨在研究美国密歇根州底特律市主要道路附近的哮喘儿童队列中近道路暴露于空气污染物和呼吸结果之间的关系。从2010年9月到2012年12月，共有139名6-14岁的哮喘儿童参加了这项研究，他们的家靠近柴油交通量不同的主要道路。该研究的目的是调查交通相关暴露对不良呼吸结果的影响，炎症和氧化应激的生物分子标志物，以及这些暴露如何影响哮喘儿童队列中呼吸道病毒感染的频率和严重程度。一个综合的测量和建模方法被用来定量估计交通源的贡献，近道路空气污染和评估预测模型，用于评估近道路污染对儿童的暴露的影响。在2010年秋季和2011年春季进行了两次密集的实地活动，以测量一套空气污染物，包括PM2.5质量和组成，氮氧化物（NO和NO2），一氧化碳，黑碳室内和室外的25名参与者的家，在两个地区的学校，和沿着一个空间样带相邻的I-96，在底特律的主要高速公路。这些数据用于评估和改进模型，以估计每个儿童每天的空气质量和暴露量，以进行健康分析。研究的设计和方法进行了说明，并选择测量结果从2010年秋季现场密集展示的设计和成功实施的研究。这些数据提供了道路影响和研究参与者之间的暴露变异性的证据，将进一步探讨与健康措施的关联。
The Near-Road Exposures and Effects of Urban Air Pollutants Study (NEXUS) was designed to examine the relationship between near-roadway exposures to air pollutants and respiratory outcomes in a cohort of asthmatic children who live close to major roadways in Detroit, Michigan USA. From September 2010 to December 2012 a total of 139 children with asthma, ages 6–14, were enrolled in the study on the basis of the proximity of their home to major roadways that carried different amounts of diesel traffic. The goal of the study was to investigate the effects of traffic-associated exposures on adverse respiratory outcomes, biomolecular markers of inflammatory and oxidative stress, and how these exposures affect the frequency and severity of respiratory viral infections in a cohort of children with asthma. An integrated measurement and modeling approach was used to quantitatively estimate the contribution of traffic sources to near-roadway air pollution and evaluate predictive models for assessing the impact of near-roadway pollution on children’s exposures. Two intensive field campaigns were conducted in Fall 2010 and Spring 2011 to measure a suite of air pollutants including PM2.5 mass and composition, oxides of nitrogen (NO and NO2), carbon monoxide, and black carbon indoors and outdoors of 25 participants’ homes, at two area schools, and along a spatial transect adjacent to I-96, a major highway in Detroit. These data were used to evaluate and refine models to estimate air quality and exposures for each child on a daily basis for the health analyses. The study design and methods are described, and selected measurement results from the Fall 2010 field intensive are presented to illustrate the design and successful implementation of the study. These data provide evidence of roadway impacts and exposure variability between study participants that will be further explored for associations with the health measures.
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DOI：
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发表时间：
2008-12-01
影响因子：
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作者：
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通讯作者：
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影响因子：
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影响因子：
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影响因子：
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