dbCRID: a database of chromosomal rearrangements in human diseases.
dbCRID: a database of chromosomal rearrangements in human diseases.
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DOI：
10.1093/nar/gkq1038
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发表时间：
2011-01
影响因子：
14.9
通讯作者：
Li T
中科院分区：
文献类型：
--
作者：
Kong F;Zhu J;Wu J;Peng J;Wang Y;Wang Q;Fu S;Yuan LL;Li T
染色体重排（CR）事件是由DNA分子的异常断裂和重新连接或重复DNA序列之间的交叉引起的，它与许多肿瘤和非肿瘤疾病有关。对疾病相关的CR事件的研究不仅可以发现DNA断裂和修复机制的重要发现，而且可以为这些疾病的病理原因和诊断/治疗靶点提供重要线索。我们开发了疾病染色体重排数据库（dbCRID, http://dbCRID.biolead.org），这是一个关于人类CR事件及其相关疾病的综合数据库。对于每个报告的CR事件，dbCRID记录了事件的类型、相关的疾病或症状，并在可能的情况下记录了CR事件的详细信息，包括精确的断点位置、连接序列、被破坏的基因和基因区域以及用于发现/分析CR事件的实验技术。dbCRID收录了来自1172项原始研究的2643条疾病相关CR事件记录，是研究DNA断裂和修复机制、分析人类肿瘤和非肿瘤疾病遗传基础的综合性动态资源。
Chromosomal rearrangement (CR) events result from abnormal breaking and rejoining of the DNA molecules, or from crossing-over between repetitive DNA sequences, and they are involved in many tumor and non-tumor diseases. Investigations of disease-associated CR events can not only lead to important discoveries about DNA breakage and repair mechanisms, but also offer important clues about the pathologic causes and the diagnostic/therapeutic targets of these diseases. We have developed a database of Chromosomal Rearrangements In Diseases (dbCRID, http://dbCRID.biolead.org), a comprehensive database of human CR events and their associated diseases. For each reported CR event, dbCRID documents the type of the event, the disease or symptoms associated, and—when possible—detailed information about the CR event including precise breakpoint positions, junction sequences, genes and gene regions disrupted and experimental techniques applied to discover/analyze the CR event. With 2643 records of disease-associated CR events curated from 1172 original studies, dbCRID is a comprehensive and dynamic resource useful for studying DNA breakage and repair mechanisms, and for analyzing the genetic basis of human tumor and non-tumor diseases.
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影响因子：
64.8
作者：
通讯作者：
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影响因子：
30.8
作者：
Speicher, MR;Ballard, SG;Ward, DC
通讯作者：
Ward, DC
影响因子：
14.9
作者：
Hubbard, T;Barker, D;Clamp, M
通讯作者：
Clamp, M
影响因子：
3.7
作者：
Knutsen, T;Gobu, V;Ried, T
通讯作者：
Ried, T
影响因子：
7
作者：
Stein, LD;Mungall, C;Lewis, S
通讯作者：
Lewis, S