Functional and Potential Therapeutic Implication of MicroRNAs in Pancreatic Cancer.
Functional and Potential Therapeutic Implication of MicroRNAs in Pancreatic Cancer.
复制标题
microRNAs在胰腺癌中的功能和潜在治疗意义。
DOI：
10.3390/ijms242417523
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发表时间：
2023-12-15
影响因子：
5.6
通讯作者：
Ju, Jingfang
中科院分区：
文献类型：
--
作者：
Pal, Amartya;Ojha, Anushka;Ju, Jingfang
胰腺癌的五年生存率低得惊人，这是一个全球性的健康挑战，占所有癌症相关死亡的7%。晚期诊断和高度异质性是胰腺癌治疗的最大障碍。因此，迫切需要发现新的生物标志物，可以帮助早期检测以及改善治疗策略。MicroRNA（miRNAs）是一类短的非编码RNA，在诊断和治疗方面都有很好的应用前景。在胰腺癌中，失调的miRNAs在加速肿瘤生长和转移、协调肿瘤微环境和赋予化疗耐药性中起关键作用。miRNAs在胰腺癌中的差异表达谱可用于探索新的治疗策略。在这篇综述中，我们还涵盖了各种基于miRNA的治疗方法的最新进展，如恢复具有肿瘤抑制功能的miRNA，抑制具有致癌功能的miRNA，以及与化疗药物的组合。尽管在特异性和靶向递送方面存在一些挑战，但基于miRNA的疗法具有通过同时靶向多种信号通路来彻底改变胰腺癌治疗的潜力。
The alarmingly low five-year survival rate for pancreatic cancer presents a global health challenge, contributing to about 7% of all cancer-related deaths. Late-stage diagnosis and high heterogeneity are the biggest hurdles in treating pancreatic cancer. Thus, there is a pressing need to discover novel biomarkers that could help in early detection as well as improve therapeutic strategies. MicroRNAs (miRNAs), a class of short non-coding RNA, have emerged as promising candidates with regard to both diagnostics and therapeutics. Dysregulated miRNAs play pivotal roles in accelerating tumor growth and metastasis, orchestrating tumor microenvironment, and conferring chemoresistance in pancreatic cancer. The differential expression profiles of miRNAs in pancreatic cancer could be utilized to explore novel therapeutic strategies. In this review, we also covered studies on recent advancements in various miRNA-based therapeutics such as restoring miRNAs with a tumor-suppressive function, suppressing miRNA with an oncogenic function, and combination with chemotherapeutic drugs. Despite several challenges in terms of specificity and targeted delivery, miRNA-based therapies hold the potential to revolutionize the treatment of pancreatic cancer by simultaneously targeting multiple signaling pathways.
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MicroRNA-506 在胰腺导管腺癌的发展过程中上调，并与疾病进展减弱相关
影响因子：
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作者：
Cheng RF;Wang J;Zhang JY;Sun L;Zhao YR;Qiu ZQ;Sun BC;Sun Y
通讯作者：
Sun Y
影响因子：
11.2
作者：
通讯作者：
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活化星状细胞介导的旁分泌信号、代谢和肿瘤免疫学在胰腺导管腺癌中的关键作用
影响因子：
37.3
作者：
Fu Y;Liu S;Zeng S;Shen H
通讯作者：
Shen H
影响因子：
4.6
作者：
Qi, Wenxin;Liu, Qian;Fu, Wenjun;Shi, Jiaming;Shi, Minmin;Duan, Songqi;Li, Zhe;Song, Shaohua;Wang, Jiao;Liu, Yihao
通讯作者：
Liu, Yihao
DOI：
10.1097/jp9.0000000000000029
发表时间：
2019-12-01
期刊：
Journal of pancreatology
影响因子：
--
作者：
Fesler, Andrew;Ju, Jingfang
通讯作者：
Ju, Jingfang