Nucleus accumbens circuit disinhibits lateral hypothalamus glutamatergic neurons contributing to morphine withdrawal memory in male mice.
Nucleus accumbens circuit disinhibits lateral hypothalamus glutamatergic neurons contributing to morphine withdrawal memory in male mice.
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DOI：
10.1038/s41467-022-35758-5
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发表时间：
2023-01-05
影响因子：
16.6
通讯作者：
Zheng, Ping
中科院分区：
文献类型：
--
作者：
Sheng, Huan;Lei, Chao;Yuan, Yu;Fu, Yali;Cui, Dongyang;Yang, Li;Shao, Da;Cao, Zixuan;Yang, Hao;Guo, Xinli;Chu, Chenshan;Wen, Yaxian;Cai, Zhangyin;Chen, Ming;Lai, Bin;Zheng, Ping
外侧下丘脑（LH）在脑功能中具有重要的生理学意义。LH在药物成瘾中也起着重要作用。然而，LH参与药物成瘾的神经回路仍然不清楚。本研究结果表明，在雄性小鼠吗啡戒断记忆的情境诱导表达过程中，LH能神经元起着重要作用，中脑背外侧核（NAcC）投射到LH的多巴胺D1受体阳性中棘神经元（D1-MSNs）是激活LH能神经元的重要上游通路; D1-MSNs从NAcC投射到LH，通过抑制LH局部γ-氨基丁酸（GABA）神经元激活LH能神经元。这些结果表明，来自NAcC的神经回路对LH能神经元的去抑制在情境诱导的吗啡戒断记忆表达中起重要作用。外侧下丘脑（LH）在药物成瘾中起作用。在这里，作者提出的证据，解除抑制的LH受体能神经元的神经回路，从脑桥，有助于上下文诱导的表达吗啡戒断记忆。
The lateral hypothalamus (LH) is physiologically critical in brain functions. The LH also plays an important role in drug addiction. However, neural circuits underlying LH involvement of drug addiction remain obscure. In the present study,our results showed that in male mice, during context-induced expression of morphine withdrawal memory, LH glutamatergic neurons played an important role; dopamine D1 receptor-expressing medium spiny neurons (D1-MSNs) projecting from the core of nucleus accumbens (NAcC) to the LH were an important upstream circuit to activate LH glutamatergic neurons; D1-MSNs projecting from the NAcC to the LH activated LH glutamatergic neurons through inhibiting LH local gamma-aminobutyric acid (GABA) neurons. These results suggest that disinhibited LH glutamatergic neurons by neural circuits from the NAcC importantly contribute to context-induced the expression of morphine withdrawal memory. Lateral hypothalamus (LH) plays an role in drug addiction. Here, authors present evidence for disinhibited LH glutamatergic neurons by neural circuits from nucleus accumbens to contribute to context-induced expression of morphine withdrawal memory.
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影响因子：
16.2
作者：
Keyes PC;Adams EL;Chen Z;Bi L;Nachtrab G;Wang VJ;Tessier-Lavigne M;Zhu Y;Chen X
通讯作者：
Chen X
影响因子：
16.2
作者：
Borgland, SL;Taha, SA;Bonci, A
通讯作者：
Bonci, A
影响因子：
56.9
作者：
Fremeau, RT;Kam, K;Edwards, RH
通讯作者：
Edwards, RH
DOI：
10.1073/pnas.0504438102
发表时间：
2005-08-09
影响因子：
11.1
作者：
Ahmed, SH;Lutjens, R;Sanna, PP
通讯作者：
Sanna, PP
影响因子：
3.3
作者：
Hamlin, A. S.;Clemens, K. J.;Mcnally, G. P.
通讯作者：
Mcnally, G. P.