Plasma Acylcarnitines during Pregnancy and Neonatal Anthropometry: A Longitudinal Study in a Multiracial Cohort.
Plasma Acylcarnitines during Pregnancy and Neonatal Anthropometry: A Longitudinal Study in a Multiracial Cohort.
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DOI：
10.3390/metabo11120885
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发表时间：
2021-12-17
期刊：
影响因子：
4.1
通讯作者：
Zhang C
中科院分区：
文献类型：
--
作者：
Song Y;Lyu C;Li M;Rahman ML;Chen Z;Zhu Y;Hinkle SN;Chen L;Mitro SD;Li LJ;Weir NL;Tsai MY;Zhang C
作为反映线粒体功能障碍的替代读数，血浆酰基肉碱水平升高与肥胖、妊娠糖尿病和 2 型糖尿病等心脏代谢疾病有关。本研究旨在探讨妊娠期酰基肉碱谱与新生儿人体测量学之间的前瞻性关联，包括出生体重、出生体重 z 评分、体长、皮褶总和以及体围总和。我们使用电喷雾电离串联质谱法对来自国家儿童健康和人类发展研究所 (NICHD) 胎儿生长研究单例的 321 名孕妇在妊娠第 10-14 周、15-26、23-31 和 33-39 周收集的血浆中的 28 种酰基肉碱进行了定量。应用潜在类轨迹方法来识别妊娠期间酰基肉碱的轨迹。我们使用加权广义线性模型检查了个体酰基肉碱和不同轨迹组与新生儿人体测量的关联，并调整了母亲年龄、种族/民族、教育程度、产次、采血孕龄和孕前体重指数（BMI）。我们分别在 C2、C3 和 C4 中确定了三个不同的轨迹组，在 C5、C10、C5-DC、C8:1、C10:1 和 C12 中分别确定了两个轨迹组。与C12水平持续稳定的女性(94.3%)相比，妊娠期C12水平呈非线性下降的女性(5.7%)的后代出生体重(−475 g；95% CI，−942，−6.79)、出生体重z评分(−0.39，−0.71，−0.06)和出生身长(−1.38 cm，−2.49，−0.27)显着较低(所有标称 p 值 < 0.05)。怀孕期间 C10 水平持续较高的女性 (6.1%) 的后代皮褶总和 (4.91 mm, 0.85, 8.98) 比 C10:1 水平较低的女性 (93.9%) 更厚，而 C10:1 水平较低的女性 (12.6%) 的后代皮褶总和比突然增加的女性更厚 (3.23 mm, 0.19, 6.27) (87.4%) (p < 0.05)。总之，这项研究表明，整个怀孕期间 C10、C10:1 和 C12 酰基肉碱水平的独特轨迹与新生儿人体测量学显着相关。
As surrogate readouts reflecting mitochondrial dysfunction, elevated levels of plasma acylcarnitines have been associated with cardiometabolic disorders, such as obesity, gestational diabetes, and type 2 diabetes. This study aimed to examine prospective associations of acylcarnitine profiles across gestation with neonatal anthropometry, including birthweight, birthweight z score, body length, sum of skinfolds, and sum of body circumferences. We quantified 28 acylcarnitines using electrospray ionization tandem mass spectrometry in plasma collected at gestational weeks 10–14, 15–26, 23–31, and 33–39 among 321 pregnant women from the National Institute of Child Health and Human Development (NICHD) Fetal Growth Studies-Singletons. A latent-class trajectory approach was applied to identify trajectories of acylcarnitines across gestation. We examined the associations of individual acylcarnitines and distinct trajectory groups with neonatal anthropometry using weighted generalized linear models adjusting for maternal age, race/ethnicity, education, parity, gestational age at blood collection, and pre-pregnancy body mass index (BMI). We identified three distinct trajectory groups in C2, C3, and C4 and two trajectory groups in C5, C10, C5–DC, C8:1, C10:1, and C12, respectively. Women with nonlinear decreasing C12 levels across gestation (5.7%) had offspring with significantly lower birthweight (−475 g; 95% CI, −942, −6.79), birthweight z score (−0.39, −0.71, −0.06), and birth length (−1.38 cm, −2.49, −0.27) than those with persistently stable C12 levels (94.3%) (all nominal p value < 0.05). Women with consistently higher levels of C10 (6.1%) had offspring with thicker sum of skinfolds (4.91 mm, 0.85, 8.98) than did women with lower levels (93.9%) during pregnancy, whereas women with lower C10:1 levels (12.6%) had offspring with thicker sum of skinfolds (3.23 mm, 0.19, 6.27) than did women with abruptly increasing levels (87.4%) (p < 0.05). In conclusion, this study suggests that distinctive trajectories of C10, C10:1, and C12 acylcarnitine levels throughout pregnancy were significantly associated with neonatal anthropometry.
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影响因子：
64.5
作者：
Muoio DM
通讯作者：
Muoio DM
影响因子：
16.2
作者：
Lowe WL Jr;Bain JR;Nodzenski M;Reisetter AC;Muehlbauer MJ;Stevens RD;Ilkayeva OR;Lowe LP;Metzger BE;Newgard CB;Scholtens DM;HAPO Study Cooperative Research Group
通讯作者：
HAPO Study Cooperative Research Group
影响因子：
7.7
作者：
Grewal, Jagteshwar;Grantz, Katherine L.;Louis, Germaine M. Buck
通讯作者：
Louis, Germaine M. Buck
影响因子：
8.2
作者：
Kadakia, Rachel;Nodzenski, Michael;Lowe, William L., Jr.
通讯作者：
Lowe, William L., Jr.
影响因子：
9.8
作者：
Buck Louis GM;Grewal J;Albert PS;Sciscione A;Wing DA;Grobman WA;Newman RB;Wapner R;D'Alton ME;Skupski D;Nageotte MP;Ranzini AC;Owen J;Chien EK;Craigo S;Hediger ML;Kim S;Zhang C;Grantz KL
通讯作者：
Grantz KL