Morphometric differences in planum temporale in schizophrenia and bipolar disorder revealed by statistical analysis of labeled cortical depth maps.
Morphometric differences in planum temporale in schizophrenia and bipolar disorder revealed by statistical analysis of labeled cortical depth maps.
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DOI：
10.3389/fpsyt.2014.00094
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发表时间：
2014
影响因子：
4.7
通讯作者：
Barta PE
中科院分区：
文献类型：
--
作者：
Ratnanather JT;Cebron S;Ceyhan E;Postell E;Pisano DV;Poynton CB;Crocker B;Honeycutt NA;Mahon PB;Barta PE
在精神分裂症（SCZ）和双相情感障碍（BPD）患者的MRI研究中，已经报道了外侧颞叶（包括颞平面（PT））皮质厚度的差异。这些研究中的大多数都使用了单值的整体或局部厚度测量。然而，可以通过生成标记的皮层距离图（LCDM）来获得附加的和补充的信息，所述标记的皮层距离图是标记的灰质（GM）体素与GM/白色物质（WM）（内部）皮层表面上的最近点的距离。合并和删失LCDM距离的统计分析显示，根据Ratnanather等人（Schizophrenia Research）生成的数据，SCZ和BPD组之间PT存在细微差异。这些结果证实，左颞平面（LPT）在区分SCZ、BPD和健康对照方面比右PT更敏感。还证实了强烈的性别效应，在男性中观察到的PT比女性更厚。通过合并和删失LCDM分析显示，LPT中较小距离处的组间差异表明SCZ和BPD对靠近GM/WM表面的皮质套具有不同的影响。这与尸检研究中观察到的皮质外套的细微变化一致。
Differences in cortical thickness in the lateral temporal lobe, including the planum temporale (PT), have been reported in MRI studies of schizophrenia (SCZ) and bipolar disorder (BPD) patients. Most of these studies have used a single-valued global or local measure for thickness. However, additional and complementary information can be obtained by generating labeled cortical distance maps (LCDMs), which are distances of labeled gray matter (GM) voxels from the nearest point on the GM/white matter (WM) (inner) cortical surface. Statistical analyses of pooled and censored LCDM distances reveal subtle differences in PT between SCZ and BPD groups from data generated by Ratnanather et al. (Schizophrenia Research, ). These results confirm that the left planum temporale (LPT) is more sensitive than the right PT in distinguishing between SCZ, BPD, and healthy controls. Also confirmed is a strong gender effect, with a thicker PT seen in males than in females. The differences between groups at smaller distances in the LPT revealed by pooled and censored LCDM analysis suggest that SCZ and BPD have different effects on the cortical mantle close to the GM/WM surface. This is consistent with reported subtle changes in the cortical mantle observed in post-mortem studies.
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