Additive effect of atropine eye drops and short-term retinal defocus on choroidal thickness in children with myopia.
Additive effect of atropine eye drops and short-term retinal defocus on choroidal thickness in children with myopia.
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DOI：
10.1038/s41598-020-75342-9
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发表时间：
2020-10-27
影响因子：
4.6
通讯作者：
Phillips JR
中科院分区：
文献类型：
--
作者：
Chiang ST;Turnbull PRK;Phillips JR
阿托品滴眼液和近视视网膜散焦可减缓近视（近视）的进展。它们还会导致脉络膜增厚，并且有人认为，脉络膜增厚是眼睛生长减少和近视进展减慢的先兆。我们研究了当同时使用两者时，由于光学散焦引起的脉络膜增厚是否会增加由于阿托品引起的脉络膜增厚。此外，这两种临床治疗方法的结合可能会提高近视控制的效果。我们对 20 名儿童进行了为期 6 个月的研究，每天服用 0.3% 阿托品来控制近视。我们在阿托品治疗 1 周、3 个月和 6 个月之前和之后实施了短期视网膜散焦（1 小时近视或远视散焦 (± 2.00D)）。在使用阿托品之前，近视或远视散焦分别导致脉络膜显着变厚或变薄（± 12 µm，p< 0.001）。单独使用阿托品一周后，厚度增加（+ 21 µm；SD 17 µm；p< 0.001），并且当暴露于近视散焦时，厚度进一步增加（+ 13 µm；SD 6 µm；p< 0.001）。阿托品消除了因远视散焦而导致的脉络膜变薄。阿托品治疗 3 个月和 6 个月后，这些效果保持不变。我们的结果表明，阿托品和光学散焦的累加效应存在于脉络膜水平，并表明光学治疗和药物治疗相结合可能会增强临床近视控制的功效。
Atropine eye drops and myopic retinal defocus each slow progression of myopia (short-sight). They also cause thickening of the choroid, and it has been suggested that the thickening is a precursor for reduced eye growth and slowed myopia progression. We investigated whether choroidal thickening due to optical defocus would add to thickening due to atropine when both were applied simultaneously. Addition would suggest that combining the two clinical treatments may improve efficacy of myopia control. We studied 20 children receiving 0.3% atropine daily for myopia control, over a period of 6 months. We imposed short periods of retinal defocus (1 h of myopic or hyperopic defocus (± 2.00D)) both before, and after 1 week and 3 and 6 months of atropine treatment. Prior to atropine, myopic or hyperopic defocus caused significantly thicker or thinner choroids respectively (± 12 µm, p < 0.001). After one week of atropine alone, thickness had increased (+ 21 µm; SD 17 µm; p < 0.001), and it increased further (by + 13 µm; SD 6 µm; p < 0.001) when exposed to myopic defocus. Atropine abolished choroidal thinning in response to hyperopic defocus. These effects remained the same after 3 and 6 months of atropine treatment. Our results show that additive effects of atropine and optical defocus are present at the level of the choroid, and suggest that combining optical and pharmaceutical treatments is likely to enhance efficacy of clinical myopia control.
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