Emergence of a novel avian pox disease in British tit species.
Emergence of a novel avian pox disease in British tit species.
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DOI：
10.1371/journal.pone.0040176
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Cunningham AA
中科院分区：
文献类型：
--
作者：
Lawson B;Lachish S;Colvile KM;Durrant C;Peck KM;Toms MP;Sheldon BC;Cunningham AA
禽痘是一种宿主范围广泛的病毒性疾病。在英国，2006年在英格兰东南部的一只大山雀（Parus major）中首次诊断出Paridae家族鸟类的禽痘。从那以后，每年都报告了越来越多的山鸡科禽痘事件，表明出现了紧急感染。在这里，我们利用一个数据库的花园鸟类死亡率和发病率的机会性报告，分析空间和时间模式的怀疑禽痘在整个英国，2006-2010年。受影响的山鸡科报告（211起事件）超过了非山鸡科的报告（91起事件）。大多数（90%）的山雀事件涉及大山雀。与非山鸡科宿主（31.9%）相比，山鸡科痘事件更可能涉及多个个体（77.3%）。与英国非Paridae禽痘中常见的小疣样病变不同，Paridae的病变通常较大，通常具有溃疡表面和干酪样核心。空间分析显示，强集群的疑似禽痘事件涉及Paridae主机，但只有弱，不一致的集群的事件涉及非Paridae主机。Paridae和非Paridae事件之间没有空间关联。我们记录了显着的空间传播的Paridae痘起源于英格兰东南部，没有空间传播是明显的非Paridae痘。对于两个寄主分支，在8月/9月有一个年度报告高峰。禽痘病毒4 b核心蛋白的测序从英国测试的20只大山雀中的每一只产生了相同的病毒序列。这一序列与中欧和斯堪的纳维亚的大山雀的序列相同。与此相反，序列变异是明显的，从17个非Paridae主机的5个物种之间的病毒测试。我们的研究结果表明，Paridae痘是英国野生鸟类中一种新出现的传染病，显然起源于来自中欧或斯堪的纳维亚半岛的病毒入侵。
Avian pox is a viral disease with a wide host range. In Great Britain, avian pox in birds of the Paridae family was first diagnosed in a great tit (Parus major) from south-east England in 2006. An increasing number of avian pox incidents in Paridae have been reported each year since, indicative of an emergent infection. Here, we utilise a database of opportunistic reports of garden bird mortality and morbidity to analyse spatial and temporal patterns of suspected avian pox throughout Great Britain, 2006–2010. Reports of affected Paridae (211 incidents) outnumbered reports in non-Paridae (91 incidents). The majority (90%) of Paridae incidents involved great tits. Paridae pox incidents were more likely to involve multiple individuals (77.3%) than were incidents in non-Paridae hosts (31.9%). Unlike the small wart-like lesions usually seen in non-Paridae with avian pox in Great Britain, lesions in Paridae were frequently large, often with an ulcerated surface and caseous core. Spatial analyses revealed strong clustering of suspected avian pox incidents involving Paridae hosts, but only weak, inconsistent clustering of incidents involving non-Paridae hosts. There was no spatial association between Paridae and non-Paridae incidents. We documented significant spatial spread of Paridae pox from an origin in south-east England; no spatial spread was evident for non-Paridae pox. For both host clades, there was an annual peak of reports in August/September. Sequencing of the avian poxvirus 4b core protein produced an identical viral sequence from each of 20 great tits tested from Great Britain. This sequence was identical to that from great tits from central Europe and Scandinavia. In contrast, sequence variation was evident amongst virus tested from 17 non-Paridae hosts of 5 species. Our findings show Paridae pox to be an emerging infectious disease in wild birds in Great Britain, apparently originating from viral incursion from central Europe or Scandinavia.
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影响因子：
2.5
作者：
Lawson, B.;Howard, T.;Cunningham, Andrew A.
通讯作者：
Cunningham, Andrew A.
影响因子：
0.3
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