Gingiva-Derived Mesenchymal Stem Cells: Potential Application in Tissue Engineering and Regenerative Medicine - A Comprehensive Review.
Gingiva-Derived Mesenchymal Stem Cells: Potential Application in Tissue Engineering and Regenerative Medicine - A Comprehensive Review.
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DOI：
10.3389/fimmu.2021.667221
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发表时间：
2021
影响因子：
7.3
通讯作者：
Le AD
中科院分区：
文献类型：
--
作者：
Kim D;Lee AE;Xu Q;Zhang Q;Le AD
一个独特的间充质干细胞亚群(MSCs)已从人牙龈组织(GMSCs)中分离和鉴定。与来源于骨髓、脂肪或脐带等其他组织来源的MSCs相似，GMSCs还具有多向分化能力，通过分泌具有免疫抑制和抗炎功能的各种生物活性因子，对天然免疫细胞和获得性免疫细胞具有强大的免疫调节作用。独一无二的是，GMSCs具有高度的增殖性，并有分化为神经细胞系的倾向，这是由于神经脊起源的缘故。这些特性使GMSCs在各种人类疾病的临床前模型中具有强大的再生和治疗潜力，特别是一些炎症性和自身免疫性疾病、皮肤病、口腔颌面部疾病和周围神经损伤。所有类型的细胞都会释放胞外囊泡(EV)，包括外体，这些EV通过含有各种生物活性分子的货物在细胞间的交流中发挥关键作用，如蛋白质、核酸和脂类。与其他来源的MSCs释放的EVS一样，GMSC来源的EVS在几种临床前疾病模型中具有与GMSCs相似的生物学功能和治疗效果，因此是一种很有前途的无细胞再生治疗平台。综上所述，由于牙周组织的易获得性和较低的发病率，以及强大的免疫调节和抗炎功能，GMSCs是一种独特的神经峰源性MSCs来源，在组织工程和再生治疗中具有潜在的应用前景。
A unique subpopulation of mesenchymal stem cells (MSCs) has been isolated and characterized from human gingival tissues (GMSCs). Similar to MSCs derived from other sources of tissues, e.g. bone marrow, adipose or umbilical cord, GMSCs also possess multipotent differentiation capacities and potent immunomodulatory effects on both innate and adaptive immune cells through the secretion of various types of bioactive factors with immunosuppressive and anti-inflammatory functions. Uniquely, GMSCs are highly proliferative and have the propensity to differentiate into neural cell lineages due to the neural crest-origin. These properties have endowed GMSCs with potent regenerative and therapeutic potentials in various preclinical models of human disorders, particularly, some inflammatory and autoimmune diseases, skin diseases, oral and maxillofacial disorders, and peripheral nerve injuries. All types of cells release extracellular vesicles (EVs), including exosomes, that play critical roles in cell-cell communication through their cargos containing a variety of bioactive molecules, such as proteins, nucleic acids, and lipids. Like EVs released by other sources of MSCs, GMSC-derived EVs have been shown to possess similar biological functions and therapeutic effects on several preclinical diseases models as GMSCs, thus representing a promising cell-free platform for regenerative therapy. Taken together, due to the easily accessibility and less morbidity of harvesting gingival tissues as well as the potent immunomodulatory and anti-inflammatory functions, GMSCs represent a unique source of MSCs of a neural crest-origin for potential application in tissue engineering and regenerative therapy.
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DOI：
10.1111/j.1365-2222.2010.03685.x
发表时间：
2011-04
期刊：
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
影响因子：
--
作者：
Brown JM;Nemeth K;Kushnir-Sukhov NM;Metcalfe DD;Mezey E
通讯作者：
Mezey E
影响因子：
4.3
作者：
Fawzy El-Sayed, Karim M.;Nguyen, Nhung;Doerfer, Christof E.
通讯作者：
Doerfer, Christof E.
影响因子：
7.5
作者：
Diomede F;Gugliandolo A;Cardelli P;Merciaro I;Ettorre V;Traini T;Bedini R;Scionti D;Bramanti A;Nanci A;Caputi S;Fontana A;Mazzon E;Trubiani O
通讯作者：
Trubiani O
影响因子：
4.3
作者：
Fawzy El-Sayed KM;Dörfer CE
通讯作者：
Dörfer CE
人牙龈源性间充质干细胞通过靶向CD39(-)CD73信号通路治疗狼疮性肾炎
影响因子：
12.8
作者：
Dang, Junlong;Xu, Zhenjian;Zheng, Song Guo
通讯作者：
Zheng, Song Guo