Risk of stillbirth in relation to maternal haemoglobin concentration during pregnancy.
Risk of stillbirth in relation to maternal haemoglobin concentration during pregnancy.
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死产风险与怀孕期间母亲血红蛋白浓度有关。
DOI：
10.1111/j.1740-8709.2006.00044.x
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发表时间：
2006
影响因子：
3.4
通讯作者：
Cogswell,MaryE
中科院分区：
文献类型：
--
作者：
Tomashek,KayM;Ananth,CandeV;Cogswell,MaryE
The authors determined the association between maternal haemoglobin concentration measured at <28 weeks’ gestation and late fetal death at ≥28 weeks’ gestation (stillbirth). Data were derived from the National Maternal and Infant Health Survey – a nationally representative survey of US deliveries in 1988. Analysis was restricted to women with a singleton live birth (n= 4199) or a stillbirth (n= 1375) for whom maternal prenatal care, haemoglobin, smoking status and gestational age data were available. Haemoglobin concentrations during first and second trimesters, respectively, were classified as mild (10.0 to <11.0 and 9.5 to <10.5 g dL−1) or moderate (9.0 to <10.0 and 8.5 to <9.5 g dL−1) anaemia, or high haemoglobin (≥14.6 g dL−1in either trimester). Hazard ratios (HR) and 95% confidence intervals (CI) for stillbirth were derived from discrete proportional hazards regression models after adjusting for confounders. Stillbirth was not associated with mild anaemia or high haemoglobin in either the first or second trimester of pregnancy. Moderate anaemia measured before 28 weeks’ gestation was significantly associated with an increased risk of stillbirth among non‐black women (adjusted HR: 4.4; 95% CI: 1.02, 19.01). Moderate anaemia was not associated with stillbirths among black women. Further investigation regarding causal mechanisms for this association is warranted.
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DOI：
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期刊：
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DOI：
10.1126/science.2564699
发表时间：
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期刊：
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