Threshold dose for intravenous nicotine self-administration in young adult non-dependent smokers.
Threshold dose for intravenous nicotine self-administration in young adult non-dependent smokers.
复制标题
DOI：
10.1007/s00213-021-05833-8
复制
发表时间：
2021-08
影响因子：
3.4
通讯作者：
Sofuoglu M
中科院分区：
文献类型：
--
作者：
MacLean RR;DeVito EE;Eid T;Parida S;Gueorguieva R;Sofuoglu M
减少吸入烟草产品中的尼古丁含量可能会预防尼古丁成瘾，但在受控的人体实验室研究中，尚未系统地评估尼古丁强化的阈值。本研究使用一种新的双盲安慰剂对照静脉注射尼古丁自我给药(NSA)模型，通过强制选择自我给药程序来确定尼古丁和尼古丁强化主观效应的阈值。年轻成年人(n=34)在隔夜戒烟后进行了5次实验室治疗。在每个疗程中，参与者对静脉注射尼古丁(0.0125、0.025、0.025、0.10或0.2mg尼古丁/70公斤体重)与生理盐水(安慰剂)的主观效果进行抽样和评分，然后给出总共10次自我注射尼古丁或安慰剂的机会。混合效应模型显示，在样本期间，尼古丁剂量对正效应(即“刺激性”和“愉悦性”；p<；.0001)有显著影响，但不会对“厌恶”效应产生显著影响。事后比较显示，与安慰剂和低剂量相比，较高剂量(即0.1和0.2毫克)与更大的刺激、愉悦和生理效应相关。混合效应模型显示，只有最高剂量(即0.2毫克)始终比安慰剂更受欢迎。性别差异普遍较弱(p=0.03-0.05)。使用我们的IV尼古丁NSA模型，检测年轻成年吸烟者尼古丁积极影响的阈值约为0.1毫克，但需要更高剂量的尼古丁，0.2毫克，才能产生一致的尼古丁强化。关于监管的影响，我们的发现进一步支持尼古丁强化阈值作为烟草监管目标的价值。
Reducing nicotine content of inhaled tobacco products may prevent nicotine addiction, but the threshold for nicotine reinforcement has not been systematically evaluated in controlled human laboratory studies. The current study uses a novel double-blind placebo-controlled intravenous (IV) nicotine self-administration (NSA) model to determine threshold for subjective effects of nicotine and nicotine reinforcement using a forced choice self-administration procedure. Young adults (n = 34) had 5 laboratory sessions after overnight nicotine abstinence. In each session, participants sampled and rated the subjective effects of an IV dose of nicotine (0.0125, 0.025, 0.05, 0.1, or 0.2 mg nicotine/70 kg bodyweight) versus saline (placebo), then were given a total of 10 opportunities to self-administer either the IV dose of nicotine or placebo. Mixed effect models revealed a significant effect of nicotine dose for positive (i.e., “stimulatory” and “pleasurable”; p < .0001) effects, but not “aversive” effects during sampling period. Post hoc comparisons showed that higher doses (i.e., 0.1 and 0.2 mg) were associated with greater stimulatory, pleasurable, and physiological effects than placebo and lower doses. Mixed effect models revealed that only the highest dose (i.e., 0.2 mg) was consistently preferred over placebo. Sex differences were generally weak (p = .03–.05). Using our IV nicotine NSA model, the threshold for detecting positive effects of nicotine in young adult smokers is about 0.1 mg, but a higher dose of nicotine, 0.2 mg, is required to produce a consistent nicotine reinforcement. Regarding the regulatory impact, our findings further support the value of nicotine reinforcement threshold as a tobacco regulatory target.
登录
查看更多内容
影响因子：
4.1
作者：
Valentine, Gerald W.;DeVito, Elise E.;Sofuoglu, Mehmet
通讯作者：
Sofuoglu, Mehmet
影响因子：
120.7
作者：
Hatsukami, Dorothy K.;Luo, Xianghua;Donny, Eric C.
通讯作者：
Donny, Eric C.
影响因子：
7.6
作者：
DeVito, Elise E.;Herman, Aryeh I.;Sofuoglu, Mehmet
通讯作者：
Sofuoglu, Mehmet
影响因子：
7.6
作者：
Sofuoglu, Mehmet;Yoo, Sonah;Mooney, Marc
通讯作者：
Mooney, Marc
影响因子：
7.6
作者：
Jensen, Kevin P.;DeVito, Elise E.;Sofuoglu, Mehmet
通讯作者：
Sofuoglu, Mehmet