Risk of urinary incontinence symptoms in oral contraceptive users: a national cohort study from the Swedish Twin Register.

Risk of urinary incontinence symptoms in oral contraceptive users: a national cohort study from the Swedish Twin Register.
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DOI:
10.1016/j.fertnstert.2008.07.002
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发表时间:
2009-08
影响因子:
6.7
通讯作者:
Altman D
Altman D
中科院分区:
医学2区
文献类型:
--
作者:
Iliadou A;Milsom I;Pedersen NL;Altman D

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评估口服避孕药对绝经前妇女下尿路功能障碍的影响。一项队列研究的10,791名妇女(出生于1959年至1985年)来自人口为基础的瑞典双胞胎登记谁参加了基于网络的调查常见疾病。国家注册。一个也没有。尿失禁的症状对于口服避孕药的使用者,压力性尿失禁(OR 0.57,95% CI 0.41- 0.79)、混合性尿失禁(OR 0.52,95% CI 0.31-0.89)和急迫性尿失禁(OR 0.36,95% CI 0.14-0.92)症状的风险显著降低。在调整年龄、体重指数和怀孕史后,这种减少仍然显着。还观察到口服避孕药使用者膀胱过度活动症的患病率降低,但相关性不显著(OR 0.97,95%CI 0.79-1.18)。与未避孕者相比,下尿路症状与使用左炔诺孕酮宫内节育器的妇女之间无显著相关性,但尿失禁除外(OR 0.53,95%CI 0.32-0.89)。使用口服避孕药可降低尿失禁症状的总体风险。
To assess the impact of oral contraceptives on lower urinary tract dysfunction in premenopausal women. A cohort study of 10,791 women (born 1959-1985) from the population-based Swedish Twin Register who participated in a web-based survey of common diseases. National Register. None. Symptoms of urinary incontinence. For users of oral contraception there was a significantly reduced risk for symptoms of stress urinary incontinence (OR 0.57, 95% CI 0.41- 0.79); mixed urinary incontinence (OR 0.52, 95% CI 0.31-0.89); and urgency urinary incontinence (OR 0.36, 95% CI 0.14-0.92). The reduction remained significant when adjusting for age, body mass index and pregnancy history. A reduced prevalence of symptoms of overactive bladder in oral contraceptive users was also observed although the association was non-significant (OR 0.97, 95% CI 0.79-1.18). There were no significant associations between lower urinary tract symptoms and women using a levonorgestrel-releasing intrauterine device compared to non-contraceptive users, with the exception of nocturia (OR 0.53, 95% CI 0.32-0.89). Oral contraceptive use reduces the overall risk for symptoms of urinary incontinence.
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