Application of Dental Pulp Stem Cells for Bone and Neural Tissue Regeneration in Oral and Maxillofacial Region.

Application of Dental Pulp Stem Cells for Bone and Neural Tissue Regeneration in Oral and Maxillofacial Region.
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牙髓干细胞在口腔颌面部骨和神经组织再生中的应用

DOI:
10.1155/2023/2026572
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发表时间:
2023
影响因子:
4.3
通讯作者:
Ogasawara, Toru
Ogasawara, Toru
中科院分区:
医学3区
文献类型:
--
作者:
Fujii, Yasuyuki;Hatori, Ayano;Chikazu, Daichi;Ogasawara, Toru

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在口腔颌面区域,由于骨折、癌症、先天性异常等引起的严重骨缺损的治疗仍然是一个巨大的挑战。此外,神经系统疾病经常伴随这些骨缺损或其治疗。因此,迫切需要新的骨再生技术和方法来修复神经损伤。其中,利用牙髓干细胞(DPSCs)的策略是一个很有前途的选择。人类DPSCs可以很容易地从拔出的牙齿中收集到,现在被认为是一种具有更高克隆性和增殖潜力的间充质干细胞。DPSCs作为一种用于骨和神经再生的细胞来源已经引起了人们的关注。本文综述了近年来关于DPSCs成骨或神经分化的最新研究进展,以及利用DPSCs进行骨或神经再生的方法,并讨论了DPSCs在骨和神经组织再生方面的潜力。
In the oral and maxillofacial region, the treatment of severe bone defects, caused by fractures, cancers, congenital abnormalities, etc., remains a great challenge. In addition, neurological disorders are frequently accompanied by these bone defects or the treatments for them. Therefore, novel bone regenerative techniques and methods to repair nerve injury are eagerly sought. Among them, strategies using dental pulp stem cells (DPSCs) are promising options. Human DPSCs can be collected easily from extracted teeth and are now considered a type of mesenchymal stem cell with higher clonogenic and proliferative potential. DPSCs have been getting attention as a cell source for bone and nerve regeneration. In this article, we reviewed the latest studies on osteogenic or neural differentiation of DPSCs as well as bone or neural regeneration methods using DPSCs and discussed the potential of DPSCs for bone and nerve tissue regeneration.
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