Enhanced image quality in black-blood MRI using the improved motion-sensitized driven-equilibrium (iMSDE) sequence.
Enhanced image quality in black-blood MRI using the improved motion-sensitized driven-equilibrium (iMSDE) sequence.
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DOI：
10.1002/jmri.22149
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发表时间：
2010-05
影响因子：
4.4
通讯作者：
Yuan, Chun
中科院分区：
文献类型：
--
作者：
Wang, Jinnan;Yarnykh, Vasily L.;Yuan, Chun
提出一种改进的运动敏化驱动平衡(IMSDE)脉冲序列，以提高组织信噪比(SNR)，同时保持黑血颈动脉MRI的血流抑制能力。与传统的MSDE序列相比，iMSDE序列使用一个额外的重聚焦脉冲和两个额外的梯度来实现信噪比的改善。计算机模拟和体模研究被用来评估涡流和局部B1不均匀对MSDE和iMSDE图像的SNR行为的影响。为了进一步评估iMSDE在体内带来的信噪比改善，还对5名健康志愿者进行了这两种序列的扫描。统计学比较采用配对t检验。仿真和体模研究都表明，涡流和局部B1不均匀会导致MSDE序列的图像信噪比降低，而这些因素可以用iMSDE序列部分补偿。体内比较显示，iMSDE序列显著提高了组织管腔对比噪声比和静态组织信噪比(P<；0.001)，同时保持了颈动脉MRI的低腔内信噪比。与传统的MSDE序列相比，iMSDE序列可以在不牺牲血流抑制能力和时间效率的情况下，在颈动脉MRI中获得更好的软组织SNR和CNR。
To propose an improved motion-sensitized driven-equilibrium (iMSDE) pulse sequence to enhance the tissue signal-to-noise ratio (SNR) while maintaining the same flow suppression capability in black-blood carotid artery MRI. Compared to the traditional MSDE sequence, the iMSDE sequence uses an extra refocusing pulse and two extra gradients to achieve SNR improvement. Computer simulation and phantom studies were used to evaluate both eddy currents and local B1 inhomogeneity effects on SNR behaviors on both MSDE and iMSDE images. To further assess the SNR improvements brought by iMSDE in vivo, 5 healthy volunteers were also scanned with both sequences. Paired t-test was used for statistical comparison. Both simulations and phantom studies demonstrated that eddy currents and local B1 inhomogeneity will cause image SNR reduction in the MSDE sequence, and that these factors can be partially compensated for with the iMSDE sequence. In vivo comparison showed that the iMSDE sequence significantly improved the tissue-lumen contrast-to-noise ratio (CNR) and static tissue SNR (p<0.001 for both), while maintaining low lumen SNR in carotid MRI. Compared to the traditional MSDE sequence, the iMSDE sequence can achieve improved soft tissue SNR and CNR in carotid artery MRI without sacrificing flow suppression capability and time efficiency.
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