MHC Haplotyping of SARS-CoV-2 Patients: HLA Subtypes Are Not Associated with the Presence and Severity of COVID-19 in the Israeli Population.
MHC Haplotyping of SARS-CoV-2 Patients: HLA Subtypes Are Not Associated with the Presence and Severity of COVID-19 in the Israeli Population.
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DOI：
10.1007/s10875-021-01071-x
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发表时间：
2021-08
影响因子：
9.1
通讯作者：
Louzoun Y
中科院分区：
文献类型：
--
作者：
Ben Shachar S;Barda N;Manor S;Israeli S;Dagan N;Carmi S;Balicer R;Zisser B;Louzoun Y
研究发现，在包括SARS在内的各种疾病中，人类白细胞抗原单倍型与病毒感染风险或疾病严重程度的增加有关。几种基因变异与新冠肺炎的严重程度有关。研究已经提出了关联，基于非常小的样本和大量测试的人类白细胞抗原等位基因，但还没有报道人类白细胞抗原与新冠肺炎的发病率或严重程度之间的明确关联。我们对经聚合酶链式反应检测出SARS-CoV-2感染呈阳性的以色列人进行了大规模的人类白细胞抗原分析。总体而言，72,912名已知的人类白细胞抗原单倍型个体被纳入研究，其中6413人(8.8%)通过聚合酶链式反应发现患有SARS-CoV-2。共有20,937名受试者来自德系克纳兹族(至少有2/4的祖父母)。181名患者(占感染者的2.8%)因该病住院。在以色列普通人群中，66个最常见的人类白细胞抗原基因座(在A、B、C、DQB1、DRB1这五个人类白细胞抗原亚群中)均未发现与SARS-CoV-2感染或住院有关。同样，在德系犹太人中也没有发现任何关联。此外，未发现任何一个人类白细胞抗原基因的杂合性与感染或住院之间的关联。我们得出结论，在以色列人群中，人类白细胞抗原单倍型不是SARS-CoV-2感染或严重程度的主要风险/保护因素。我们的结果表明，如果存在任何与这种疾病有关的人类白细胞抗原，它是非常微弱的，对大流行的影响也是有限的。网上版载有补充材料，可在10.1007/s10875-021-01071-x查阅。
HLA haplotypes were found to be associated with increased risk for viral infections or disease severity in various diseases, including SARS. Several genetic variants are associated with COVID-19 severity. Studies have proposed associations, based on a very small sample and a large number of tested HLA alleles, but no clear association between HLA and COVID-19 incidence or severity has been reported. We conducted a large-scale HLA analysis of Israeli individuals who tested positive for SARS-CoV-2 infection by PCR. Overall, 72,912 individuals with known HLA haplotypes were included in the study, of whom 6413 (8.8%) were found to have SARS-CoV-2 by PCR. A total of 20,937 subjects were of Ashkenazi origin (at least 2/4 grandparents). One hundred eighty-one patients (2.8% of the infected) were hospitalized due to the disease. None of the 66 most common HLA loci (within the five HLA subgroups: A, B, C, DQB1, DRB1) was found to be associated with SARS-CoV-2 infection or hospitalization in the general Israeli population. Similarly, no association was detected in the Ashkenazi Jewish subset. Moreover, no association was found between heterozygosity in any of the HLA loci and either infection or hospitalization. We conclude that HLA haplotypes are not a major risk/protecting factor among the Israeli population for SARS-CoV-2 infection or severity. Our results suggest that if any HLA association exists with the disease it is very weak, and of limited effect on the pandemic. The online version contains supplementary material available at 10.1007/s10875-021-01071-x.
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影响因子：
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作者：
Keicho N;Itoyama S;Kashiwase K;Phi NC;Long HT;Ha LD;Ban VV;Hoa BK;Hang NT;Hijikata M;Sakurada S;Satake M;Tokunaga K;Sasazuki T;Quy T
通讯作者：
Quy T
影响因子：
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作者：
Kuri-Cervantes, Leticia;Pampena, Maria Betina;Betts, Michael R.
通讯作者：
Betts, Michael R.
影响因子：
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作者：
Arora, Jatin;Pierini, Federica;Lenz, Tobias L.
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Lenz, Tobias L.
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影响因子：
2.9
作者：
Abate BB;Kassie AM;Kassaw MW;Aragie TG;Masresha SA
通讯作者：
Masresha SA
DOI：
10.1126/science.abc6261
发表时间：
2020-09-04
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Arunachalam PS;Wimmers F;Mok CKP;Perera RAPM;Scott M;Hagan T;Sigal N;Feng Y;Bristow L;Tak-Yin Tsang O;Wagh D;Coller J;Pellegrini KL;Kazmin D;Alaaeddine G;Leung WS;Chan JMC;Chik TSH;Choi CYC;Huerta C;Paine McCullough M;Lv H;Anderson E;Edupuganti S;Upadhyay AA;Bosinger SE;Maecker HT;Khatri P;Rouphael N;Peiris M;Pulendran B
通讯作者：
Pulendran B