Involvement of retrosplenial cortex in forming associations between multiple sensory stimuli.
Involvement of retrosplenial cortex in forming associations between multiple sensory stimuli.
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DOI：
10.1037/a0024262
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发表时间：
2011-08
影响因子：
1.9
通讯作者：
Bucci, David J.
中科院分区：
文献类型：
--
作者：
Robinson, Siobhan;Keene, Christopher S.;Iaccarino, Hannah F.;Duan, Daisy;Bucci, David J.
压后皮质（RSP）与内侧颞叶结构高度互连，但人们对其对学习和记忆的具体贡献知之甚少。一种可能性是 RSP 参与形成多种感觉刺激之间的关联。事实上，RSP 的损伤会扰乱对空间或情境线索的学习，也会损害对同时发生的条件刺激 (CS) 的学习。为了更严格地测试这个概念，进行了两个实验。在实验1中，大鼠接受了一系列特征负辨别任务的训练，该任务包括单独音调的强化呈现和随后有光的音调的非强化连续呈现。因此，与之前的研究相比，该范式涉及条件刺激（CS）的串行呈现，而不是同时呈现。 RSP 受损的老鼠未能获得辨别能力，这表明 RSP 是在感觉刺激之间形成关联所必需的，无论它们是连续发生还是同时发生。在实验 2 中，使用感觉预处理任务来确定 RSP 是否对于在没有强化的情况下形成刺激之间的关联是必要的。在此过程的第一阶段，将一个听觉刺激与光配对，而单独呈现第二个听觉刺激。在下一阶段的训练中，同样的灯光与食物搭配。在手术的最后阶段，两种听觉刺激均在一次治疗中单独呈现。与未配对的听觉刺激相比，对照组（而非 RSP 损伤的大鼠）在呈现先前与光配对的听觉提示后表现出更多的食物杯行为，表明在训练的第一阶段形成了刺激-刺激关联。这些结果支持 RSP 在形成环境刺激之间的关联方面发挥基础作用的观点。
The retrosplenial cortex (RSP) is highly interconnected with medial temporal lobe structures, yet relatively little is known about its specific contributions to learning and memory. One possibility is that RSP is involved in forming associations between multiple sensory stimuli. Indeed, damage to RSP disrupts learning about spatial or contextual cues and also impairs learning about co-occurring conditioned stimuli (CSs). Two experiments were conducted to test this notion more rigorously. In Experiment 1, rats were trained in a serial feature negative discrimination task consisting of reinforced presentations of a tone alone and non-reinforced serial presentations of a light followed by the tone. Thus, in contrast to prior studies, this paradigm involved serial presentation of conditioned stimuli (CS), rather than simultaneous presentation. Rats with damage to RSP failed to acquire the discrimination, indicating that RSP is required for forming associations between sensory stimuli regardless of whether they occur serially or simultaneously. In Experiment 2, a sensory preconditioning task was used to determine if RSP was necessary for forming associations between stimuli even in the absence of reinforcement. During the first phase of this procedure, one auditory stimulus was paired with a light while a second auditory stimulus was presented alone. In the next phase of training, the same light was paired with food. During the final phase of the procedure both auditory stimuli were presented alone during a single session. Control, but not RSP-lesioned rats, exhibited more food cup behavior following presentation of the auditory cue that was previously paired with light compared to the unpaired auditory stimulus, indicating that a stimulus-stimulus association was formed during the first phase of training. These results support the idea that RSP has a fundamental role in forming associations between environmental stimuli.
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影响因子：
19.9
作者：
Epstein, Russell A.
通讯作者：
Epstein, Russell A.
影响因子：
1.9
作者：
GABRIEL, M;LAMBERT, RW;MAIORCA, RR
通讯作者：
MAIORCA, RR
影响因子：
16.2
作者：
Bar, M;Aminoff, E
通讯作者：
Aminoff, E
影响因子：
2.7
作者：
Campolattaro, Matthew M.;Freeman, John H.
通讯作者：
Freeman, John H.
DOI：
10.3758/bf03212312
发表时间：
1983-01-01
期刊：
ANIMAL LEARNING & BEHAVIOR
影响因子：
--
作者：
HOLLAND, PC;ROSS, RT
通讯作者：
ROSS, RT