Alcohol consumption patterns, beverage type, and long-term mortality among women survivors of acute myocardial infarction.

Alcohol consumption patterns, beverage type, and long-term mortality among women survivors of acute myocardial infarction.
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急性心肌梗死女性幸存者的饮酒模式、饮料类型和长期死亡率。

DOI:
10.1016/j.amjcard.2011.08.021
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发表时间:
2012
期刊:
The American journal of cardiology
影响因子:
--
通讯作者:
Mittleman,MurrayA
Mittleman,MurrayA
中科院分区:
--
文献类型:
--
作者:
Rosenbloom,JoshuaI;Mukamal,KennethJ;Frost,LaurenE;Mittleman,MurrayA

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虽然适度饮酒者患冠状动脉疾病的几率比不饮酒者低,但对于患有冠状动脉疾病的女性,不同的饮酒模式对健康的影响知之甚少。在心肌梗死发病的决定因素研究中,从1989年到1996年,在全国64个中心因急性心肌梗死(MI)住院的1253名妇女的死亡率被跟踪到2007年12月31日。在这些女性中,761人(61%)报告在MIs前一年戒酒,280人(22%)报告每周食用<1份,75人(6%)报告每周食用1至3份,137人(11%)报告每周食用≥3份。使用Cox比例风险模型,研究了每周总消费量、每周饮酒天数、每天饮酒量和饮料类型与10年死亡率之间的关系,并对临床和社会经济潜在混杂因素进行了调整。与不食用相比,<1次/周的校正风险比为0.66(95%可信区间0.50 ~ 0.86),1 ~ 3次/周的校正风险比为0.65(95%可信区间0.38 ~ 1.11),≥3次/周的校正风险比为0.65(95%可信区间0.38 ~ 1.11)(趋势p = 0.008)。没有发现饮料种类的差异,一般来说,饮酒频率和数量与死亡率呈负相关。综上所述,在心肌梗死存活的女性中,适度饮酒与死亡率的降低相关,在模式或饮料类型上没有明显差异。这些结果表明,心肌梗死幸存的妇女不需要戒酒,但任何由此产生的益处似乎都远远低于目前推荐的饮酒限制。
Although moderate alcohol drinkers have lower rates of incident coronary artery disease than abstainers, much less is known about the health effects of different patterns of alcohol use in women with established coronary artery disease. In the Determinants of Myocardial Infarction Onset Study, 1,253 women hospitalized for acute myocardial infarction (MI) at 64 centers nationwide from 1989 to 1996 were followed for mortality through December 31, 2007. Of the women, 761 (61%) reported abstention in the year before their MIs, 280 (22%) reported consumption of <1 serving/week, 75 (6%) reported consumption of 1 to 3 servings/week, and 137 (11%) reported consumption of ≥3 servings/week. Using Cox proportional-hazards models, the associations between total weekly volume of consumption, drinking days per week, drinks per drinking day, and beverage type with 10-year mortality were investigated, adjusting for clinical and socioeconomic potential confounders. Compared with abstention, adjusted hazard ratios were 0.66 (95% confidence interval 0.50 to 0.86) for <1 serving/week, 0.65 (95% confidence interval 0.38 to 1.11) for 1 to 3 servings/week, and 0.65 (95% confidence interval 0.38 to 1.11) for ≥3 servings/week (p for trend = 0.008). No differences were found by beverage type, and generally inverse associations of drinking frequency and quantity with mortality were found. In conclusion, in women who survive MI, moderate drinking is associated with a decreased risk for mortality, with no clear differences on the basis of pattern or beverage type. These results suggest that women who survive MI need not abstain from alcohol, but any derived benefit would appear to occur well below currently recommended limits in alcohol consumption.
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