TOX is required for development of the CD4 T cell lineage gene program.
TOX is required for development of the CD4 T cell lineage gene program.
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DOI：
10.4049/jimmunol.1101474
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发表时间：
2011-12-01
期刊：
影响因子：
--
通讯作者：
Kaye J
中科院分区：
文献类型：
--
作者：
Aliahmad P;Kadavallore A;de la Torre B;Kappes D;Kaye J
调节CD4+ T细胞基因程序的胸腺发育的因素仍然不清楚。转录调节因子ThPOK是CD4+ T细胞发育中的主导因子，其主要功能是抑制CD8谱系命运。以前，我们表明，核蛋白TOX也需要小鼠CD4+ T细胞的发展。在这里，我们试图调查是否对TOX的需求仅仅是由于在ThPOK诱导中的作用。在明显支持这一主张，ThPOK上调和CD8谱系抑制在TOX的情况下受到损害，并加强ThPOK表达可以恢复一些CD4的发展。然而，这些“拯救”的CD4细胞在CD4+ T细胞基因程序的许多方面都有缺陷，包括Id2，Foxo1和内源性Thpok的表达等。因此，TOX对于建立CD 4 + T细胞谱系基因程序是必要的，与其对ThPOK表达的影响无关。
The factors that regulate thymic development of the CD4+ T cell gene program remain poorly defined. The transcriptional regulator ThPOK is a dominant factor in CD4+ T cell development, which functions primarily to repress the CD8 lineage fate. Previously, we showed that nuclear protein TOX is also required for murine CD4+ T cell development. Here we sought to investigate if the requirement for TOX was solely due to a role in ThPOK induction. In apparent support of this proposition, ThPOK upregulation and CD8 lineage repression were compromised in the absence of TOX, and enforced ThPOK expression could restore some CD4 development. However, these “rescued” CD4 cells were defective in many aspects of the CD4+ T cell gene program, including expression of Id2, Foxo1, and endogenous Thpok, among others. Thus, TOX is necessary to establish the CD4+ T cell lineage gene program, independent of its influence on ThPOK expression.
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影响因子：
30.5
作者：
通讯作者：
--
影响因子：
30.5
作者：
通讯作者：
--
DOI：
10.1073/pnas.95.14.8187
发表时间：
1998-07-07
影响因子：
11.1
作者：
Dave, VP;Allman, D;Kappes, DJ
通讯作者：
Kappes, DJ
影响因子：
32.4
作者：
Jones, Mary Elizabeth;Zhuang, Yuan
通讯作者：
Zhuang, Yuan
影响因子：
64.8
作者：
He, X;He, X;Kappes, DJ
通讯作者：
Kappes, DJ