Establishment and Initial Experience of Clinical FLASH Radiotherapy in Canine Cancer Patients.
Establishment and Initial Experience of Clinical FLASH Radiotherapy in Canine Cancer Patients.
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DOI：
10.3389/fonc.2021.658004
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发表时间：
2021
影响因子：
4.7
通讯作者：
Petersson K
中科院分区：
文献类型：
--
作者：
Konradsson E;Arendt ML;Bastholm Jensen K;Børresen B;Hansen AE;Bäck S;Kristensen AT;Munck Af Rosenschöld P;Ceberg C;Petersson K
与常规放疗相比，FLASH放疗已成为一种具有巨大潜力的治疗技术，可增加正常组织毒性和肿瘤反应之间的差异效应。为了评估FLASH放疗在相关临床环境中的可行性，我们已经开始了一项在患有自发性浅表实体瘤或显微镜残留病变的犬癌症患者中进行FLASH放疗的可行性和安全性研究，使用我们改良的临床直线加速器的电子束。使用标称源到表面距离为70 cm的短电子施加器和定制的Cerrobend块进行准直，建立了FLASH放射治疗的设置。通过测量不同射野尺寸的剂量分布和深度剂量曲线来表征射束。在这项初步研究中纳入了10名犬癌症患者; 7名患者有9个实体浅表肿瘤，3名患者有显微镜下疾病。给药剂量为15 ~ 35戈伊。为了确保处方剂量的正确输送，在治疗前和治疗期间进行胶片测量，并使用Farmer型离子室进行监测。治疗被认为是可行的，部分反应，完全反应或稳定的疾病记录在11/13照射肿瘤。在3-6个月的随访中观察到的不良事件为轻度，包括局部脱发、白斑、干燥脱屑、轻度红斑或肿胀。一名接受鼻平面35戈伊剂量的患者发生了3级皮肤不良事件。建立了FLASH放射治疗的剂量学程序、安全性和有效的临床工作流程。该初始研究的经验将用作兽医I/II期临床试验（具有更具体的患者入选选择）以及随后人体试验的基础。
FLASH radiotherapy has emerged as a treatment technique with great potential to increase the differential effect between normal tissue toxicity and tumor response compared to conventional radiotherapy. To evaluate the feasibility of FLASH radiotherapy in a relevant clinical setting, we have commenced a feasibility and safety study of FLASH radiotherapy in canine cancer patients with spontaneous superficial solid tumors or microscopic residual disease, using the electron beam of our modified clinical linear accelerator. The setup for FLASH radiotherapy was established using a short electron applicator with a nominal source-to-surface distance of 70 cm and custom-made Cerrobend blocks for collimation. The beam was characterized by measuring dose profiles and depth dose curves for various field sizes. Ten canine cancer patients were included in this initial study; seven patients with nine solid superficial tumors and three patients with microscopic disease. The administered dose ranged from 15 to 35 Gy. To ensure correct delivery of the prescribed dose, film measurements were performed prior to and during treatment, and a Farmer-type ion-chamber was used for monitoring. Treatments were found to be feasible, with partial response, complete response or stable disease recorded in 11/13 irradiated tumors. Adverse events observed at follow-up ranging from 3-6 months were mild and consisted of local alopecia, leukotricia, dry desquamation, mild erythema or swelling. One patient receiving a 35 Gy dose to the nasal planum, had a grade 3 skin adverse event. Dosimetric procedures, safety and an efficient clincal workflow for FLASH radiotherapy was established. The experience from this initial study will be used as a basis for a veterinary phase I/II clinical trial with more specific patient inclusion selection, and subsequently for human trials.
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影响因子：
5.7
作者：
Montay-Gruel, Pierre;Petersson, Kristoffer;Vozenin, Marie-Catherine
通讯作者：
Vozenin, Marie-Catherine
DOI：
10.1016/j.ijrobp.2021.01.011
发表时间：
2021-07-01
影响因子：
7
作者：
Rahman, Mahbubur;Ashraf, Ramish;Zhang, Rongxiao;Bruza, Petr;Dexter, Chad A.;Thompson, Lawrence;Cao, Xu;Williams, Benjamin B.;Hoopes, P. Jack;Pogue, Brian W.;Gladstone, David J.
通讯作者：
Gladstone, David J.
DOI：
10.1158/1078-0432.ccr-20-0894
发表时间：
2021-02-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Montay-Gruel P;Acharya MM;Gonçalves Jorge P;Petit B;Petridis IG;Fuchs P;Leavitt R;Petersson K;Gondré M;Ollivier J;Moeckli R;Bochud F;Bailat C;Bourhis J;Germond JF;Limoli CL;Vozenin MC
通讯作者：
Vozenin MC
影响因子：
3.8
作者：
Jaccard, Maud;Duran, Maria Teresa;Bailat, Claude
通讯作者：
Bailat, Claude
影响因子：
3.8
作者：
Jaccard, Maud;Petersson, Kristoffer;Bailat, Claude
通讯作者：
Bailat, Claude