High-Density Lipoprotein function is modulated by the SARS-CoV-2 spike protein in a lipid-type dependent manner.
High-Density Lipoprotein function is modulated by the SARS-CoV-2 spike protein in a lipid-type dependent manner.
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DOI：
10.1016/j.jcis.2023.04.137
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发表时间：
2023-09
影响因子：
9.9
通讯作者：
Cardenas, Marite
中科院分区：
文献类型：
--
作者：
Correa, Yubexi;Del Giudice, Rita;Waldie, Sarah;Thepaut, Michel;Micciula, Samantha;Gerelli, Yuri;Moulin, Martine;Delaunay, Clara;Fieschi, Franck;Pichler, Harald;Haertlein, Michael;Forsyth, V. Trevor;Le Brun, Anton;Moir, Michael;Russell, Robert A.;Darwish, Tamim;Brinck, Jonas;Wodaje, Tigist;Jansen, Martin;Martin, Cesar;Roosen-Runge, Felix;Cardenas, Marite
关键词：
SARS-CoV-2 病毒与脂蛋白，特别是高密度脂蛋白（HDL）之间存在密切关系。 2019 年冠状病毒病 (COVID-19) 的严重程度与血浆 HDL 水平呈负相关。众所周知，SARS-CoV-2 刺突 (S) 蛋白与 HDL 颗粒结合，可能会消耗其脂质并改变 HDL 功能。基于中子反射计 (NR) 和 HDL 从巨噬细胞流出胆固醇的能力，我们证实了这些观察结果，并进一步确定了 S 蛋白对特定脂质的偏好以及 HDL 功能对脂质交换能力的影响。此外，S 蛋白对 HDL 功能的影响因个体血清脂谱而异。与高甘油三酯/高胆固醇(HTHC)或低甘油三酯/低胆固醇血清水平(LTLC)相比，低甘油三酯/高胆固醇血清水平(LTHC)的个体观察到了对比趋势。总的来说，这些结果表明，S 蛋白与 HDL 颗粒相互作用，并且根据感染个体的脂质谱，它会在 COVID-19 感染期间损害其功能，导致脂质代谢失衡。
There is a close relationship between the SARS-CoV-2 virus and lipoproteins, in particular high-density lipoprotein (HDL). The severity of the coronavirus disease 2019 (COVID-19) is inversely correlated with HDL plasma levels. It is known that the SARS-CoV-2 spike (S) protein binds the HDL particle, probably depleting it of lipids and altering HDL function. Based on neutron reflectometry (NR) and the ability of HDL to efflux cholesterol from macrophages, we confirm these observations and further identify the preference of the S protein for specific lipids and the consequent effects on HDL function on lipid exchange ability. Moreover, the effect of the S protein on HDL function differs depending on the individuals lipid serum profile. Contrasting trends were observed for individuals presenting low triglycerides/high cholesterol serum levels (LTHC) compared to high triglycerides/high cholesterol (HTHC) or low triglycerides/low cholesterol serum levels (LTLC). Collectively, these results suggest that the S protein interacts with the HDL particle and, depending on the lipid profile of the infected individual, it impairs its function during COVID-19 infection, causing an imbalance in lipid metabolism.
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影响因子：
6
作者：
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通讯作者：
Lu S
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影响因子：
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通讯作者：
Cárdenas M
影响因子：
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作者：
Darwish, Tamim A.;Luks, Emily;James, Michael
通讯作者：
James, Michael