Ocular responses to antidromic trigeminal stimulation, intracameral prostaglandin E1 and E2, capsaicin and substance P.
Ocular responses to antidromic trigeminal stimulation, intracameral prostaglandin E1 and E2, capsaicin and substance P.
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眼部对逆向三叉神经刺激、前房内前列腺素 E1 和 E2、辣椒素和 P 物质的反应。
DOI：
10.1111/j.1748-1716.1981.tb06824.x
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Bill,A
中科院分区：
文献类型：
--
作者：
Mandahl,A;Bill,A
用逆行刺激三叉神经诱发急性葡萄膜炎，观察前列腺素E_1、E_2（PGE_1、PGE_2）、辣椒素和P物质（SP）对葡萄膜炎神经传导的影响。全身应用消炎痛防止内源性肾上腺素的形成，前房内注射河豚毒素（TTX）阻断神经传导。10μg TTX可防止瞳孔缩小，并可降低逆行刺激三叉神经引起的眼压升高。小剂量PGE 1可阻断TTX引起的眼压升高。在较高剂量的PGE 1和PGE 2下，TTX不能阻断压力效应，缩瞳效应明显减弱。辣椒素引起的IOP升高几乎完全被TTX阻断，而高剂量的瞳孔缩小似乎不受影响。在低剂量下，辣椒素诱导的瞳孔缩小可被TTX消除。TTX处理眼SP引起的瞳孔缩小与未处理眼相似; TTX可延迟眼压升高。结果表明，神经传导在低剂量PGE 1和辣椒素和SP引起的IOP反应中起作用。其机制是轴突反射，在前葡萄膜引起，并导致在睫状突中的递质释放。PGE 1和PGE 2的缩瞳作用似乎需要虹膜中SP或类似物质释放的神经传导。SP和辣椒素在不需要神经传导引起瞳孔缩小方面是相似的，但是辣椒素效应可能需要神经的存在，因为去神经支配的眼睛-对SP有反应-已经报道对与这里使用的剂量相似的辣椒素没有反应。
The role of nerve conduction was studied in acute experimental uveitis caused by antidromic trigeminal nerve stimulation, prostaglandin E1and E2(PGE1and PGE2), capsaicin and substance P (SP). Systemic indomethacin was used to prevent formation of endogenous prostaglandins, and intracameral injection of tetrodotoxin (TTX) was used to block nerve conduction. 10μg TTX prevented the miosis and reduced the rise in intraocular pressure (IOP) usually caused by antidromic trigeminal nerve stimulation. At a low dose of PGE1the IOP rise was blocked by TTX. At higher doses of PGE1and PGE2the pressure effect was not blocked by TTX; the miotic effect was markedly diminished. Capsaicin caused a rise in IOP that was almost totally blocked by TTX, while the miosis at high doses seemed unaffected. At low doses, capsaicin‐induced miosis could be abolished by TTX. SP caused miosis in TTX treated eyes similar to that in untreated eyes; the IOP rise was delayed by TTX. The results indicate that nerve conduction plays a role in the IOP reaction caused by low doses of PGE1and by capsaicin and SP. The mechanism suggested is an axon reflex, elicited in the anterior uvea and resulting in transmitter release in the ciliary processes. Nerve conduction with release of SP or a similar substance in the iris seems to be required for the miotic effects of PGE1and PGE2. SP and capsaicin are similar in not requiring nerve conduction to cause miosis, but the capsaicin effect probably requires presence of nerves, since denervated eyes—which respond to SP—have been reported not to respond to capsaicin doses similar to those used here.
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影响因子：
3.4
作者：
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通讯作者：
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影响因子：
7.3
作者：
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影响因子：
6.1
作者：
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通讯作者：
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影响因子：
3.4
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通讯作者：
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影响因子：
7.3
作者：
J. M. Butler;B. Hammond
通讯作者：
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