Expansion of the HSFY gene family in pig lineages
Expansion of the HSFY gene family in pig lineages
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HSFY 基因家族在猪谱系中的扩展
DOI：
10.1101/012906
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Skinner B
中科院分区：
文献类型：
--
作者：
Skinner B
研究背景性染色体上的扩增基因家族可能包含具有重要生物学功能的基因，特别是与生育有关的基因。Y连锁热休克转录因子（HSFY）家族在家猪（Sus scrofa）的Y染色体上扩增，与牛（Bos taurus）的Y染色体上的HSFY扩增明显独立。虽然HSFY基因的生物学功能知之甚少，他们似乎参与配子发生在一些哺乳动物物种，并在牛，HSFY基因拷贝数可能与水平的fertility.ResultsWe调查了HSFY家庭在家猪，和其他猪种，包括野猪，野猪，babirusa和pecaries。家猪含有至少两种扩增的HSFY变体，主要通过内含子内SINE的存在或不存在来区分。这两种变体都在睾丸中表达，并且都以大约50个拷贝存在于Y染色体短臂上的单个簇中。较长的形式具有多个无义突变，使其可能无功能，但许多较短的形式仍然具有编码潜力。其他猪种也有这两个变种的HSFY，和拷贝数的估计表明，theHSFY家族可能有独立扩增两次在猪evolution.ConclusionsTheHSFY基因已成为独立扩增在多个物种谱系。HSFY主要在家猪睾丸中表达，这一模式与牛相似，其中HSFY可能在生育中起作用。进一步研究HSFY与生育力和睾丸发育的潜在联系可能具有农业意义。
BackgroundAmplified gene families on sex chromosomes can harbour genes with important biological functions, especially relating to fertility. The Y-linked heat shock transcription factor (HSFY)family has become amplified on the Y chromosome of the domestic pig (Sus scrofa), in an apparently independent event to anHSFYexpansion on the Y chromosome of cattle (Bos taurus). Although the biological functions ofHSFYgenes are poorly understood, they appear to be involved in gametogenesis in a number of mammalian species, and, in cattle,HSFYgene copy number may correlate with levels of fertility.ResultsWe have investigated theHSFYfamily in domestic pig, and other suid species including warthog, bushpig, babirusa and peccaries. The domestic pig contains at least two amplified variants ofHSFY, distinguished predominantly by presence or absence of a SINE within the intron. Both these variants are expressed in testis, and both are present in approximately 50 copies each in a single cluster on the short arm of the Y. The longer form has multiple nonsense mutations rendering it likely non-functional, but many of the shorter forms still have coding potential. Other suid species also have these two variants ofHSFY, and estimates of copy number suggest theHSFYfamily may have amplified independently twice during suid evolution.ConclusionsTheHSFYgenes have become amplified in multiple species lineages independently. HSFY is predominantly expressed in testis in domestic pig, a pattern conserved with cattle, in which HSFY may play a role in fertility. Further investigation of the potential associations ofHSFYwith fertility and testis development may be of agricultural interest.
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影响因子：
0.7
作者：
Kinoshita, Keigo;Shinka, Toshikatsu;Nakahori, Yutaka
通讯作者：
Nakahori, Yutaka
家猫 Y 染色体 X 简并基因的基因发现和比较分析。
影响因子：
4.4
作者：
A. J. Pearks Wilkerson;T. Raudsepp;Tina Graves;Derek Albracht;W. Warren;B. Chowdhary;L. Skow;W. Murphy
通讯作者：
W. Murphy
影响因子：
10.7
作者：
K. Tamura
通讯作者：
K. Tamura
影响因子：
6.1
作者：
Kichine, Elsa;Roze, Virginie;Mitchell, Michael J.
通讯作者：
Mitchell, Michael J.
HSFY 的小鼠直系同源物的表达分析，HSFY 是人类 Y 染色体上无精子因子的候选者。
DOI：
--
发表时间：
2006
期刊：
The Journal of Medical Investigation 53
影响因子：
--
作者：
Fujita;A;Fujimoto;T;Toida K
通讯作者：
Toida K