Global analysis of phosphorylation networks in humans.
Global analysis of phosphorylation networks in humans.
复制标题
DOI：
10.1016/j.bbapap.2013.03.009
复制
发表时间：
2014-01
影响因子：
3.2
通讯作者：
Qian, Jiang
中科院分区：
文献类型：
--
作者：
Hu, Jianfei;Rho, Hee-Sool;Newman, Robert H.;Hwang, Woochang;Neiswinger, John;Zhu, Heng;Zhang, Jin;Qian, Jiang
磷酸化介导的信号转导在细胞生理学的几乎每个方面都起着至关重要的作用。最近的一项基于蛋白质微阵列实验的研究确定了大量的激酶-底物关系（KSR），并在人类中建立了一个全面可靠的磷酸化网络。对这一网络的分析，结合其他资料，揭示了几个关键特征。首先，人类和酵母的磷酸化网络的比较发现了一个进化上保守的信号转导骨干占主导地位的激酶-激酶的关系。第二，虽然大多数KSR本身并不保守，但富含给定激酶底物的功能通常是保守的。第三，激酶-转录因子调节模块的流行表明磷酸化和转录调节网络固有地连接在一起形成集成的调节电路。总体而言，这项工作中描述的磷酸化网络有望在全球和蛋白质水平上为激酶信号通路的性质提供新的见解。
Phosphorylation-mediated signaling plays a crucial role in nearly every aspect of cellular physiology. A recent study based on protein microarray experiments identified a large number of kinase-substrate relationships (KSRs), and built a comprehensive and reliable phosphorylation network in humans. Analysis of this network, in conjunction with additional resources, revealed several key features. First, comparison of the human and yeast phosphorylation networks uncovered an evolutionarily conserved signaling backbone dominated by kinase-to-kinase relationships. Second, although most of the KSRs themselves are not conserved, the functions enriched in the substrates for a given kinase are often conserved. Third, the prevalence of kinase-transcription factor regulatory modules suggests that phosphorylation and transcriptional regulatory networks are inherently wired together to form integrated regulatory circuits. Overall, the phosphorylation networks described in this work promise to offer new insights into the properties of kinase signaling pathways, at both the global and the protein levels.
登录
查看更多内容
影响因子：
46.9
作者：
Ji, Hongkai;Jiang, Hui;Ma, Wenxiu;Johnson, David S.;Myers, Richard M.;Wong, Wing H.
通讯作者：
Wong, Wing H.
影响因子：
64.8
作者：
Ptacek, J;Devgan, G;Snyder, M
通讯作者：
Snyder, M
DOI：
10.1073/pnas.0409522102
发表时间：
2005-02-08
影响因子：
11.1
作者：
Sharan, R;Suthram, S;Ideker, T
通讯作者：
Ideker, T
影响因子：
7.3
作者：
Tan, Chris Soon Heng;Bodenmiller, Bernd;Linding, Rune
通讯作者：
Linding, Rune
影响因子：
14.9
作者：
Richardson CJ;Gao Q;Mitsopoulous C;Zvelebil M;Pearl LH;Pearl FM
通讯作者：
Pearl FM