Parasites, nutrition, immune responses and biology of metabolic tissues.
Parasites, nutrition, immune responses and biology of metabolic tissues.
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DOI：
10.1111/pim.12422
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发表时间：
2017-05
影响因子：
2.2
通讯作者：
Smith A
中科院分区：
文献类型：
--
作者：
Shea-Donohue T;Qin B;Smith A
营养免疫学、免疫代谢和新的免疫靶点的鉴定是寄生虫学中活跃的研究领域。免疫细胞和代谢活性组织中的细胞之间存在有据可查的串扰，这对体内平衡很重要。这些细胞的数量和功能因肥胖而改变，导致炎症。各种蠕虫在胃肠道中度过其生命周期的一部分，甚至完全肠道线虫感染对葡萄糖和脂质代谢产生有益影响。本综述的基础是肠道线虫感染改善肥胖引起的2型糖尿病和代谢综合征的能力，这是发达地区的重要健康问题。它考虑了营养和特定营养缺乏的影响，这是发生在欠发达地区和发达地区，对主机的能力，对寄生线虫的保护性免疫反应。寄生线虫可以影响代谢的机制有很多，包括影响胃肠激素、改变上皮功能以及改变代谢组织中免疫细胞的数量和/或表型。线虫还可以通过激活转录因子STAT 6的Th 2细胞因子发挥其有益作用，STAT 6上调调节葡萄糖和脂质代谢的基因。
Nutritional immunology, immunometabolism, and identification of novel immunotherapeutic targets, are areas of active investigation in parasitology. There is a well-documented crosstalk among immune cells and cells in metabolically active tissues that is important for homeostasis. The numbers and function of these cells are altered by obesity leading to inflammation. A variety of helminths spend some part of their life cycle in the gastrointestinal tract and even entirely enteral nematode infections exert beneficial effects on glucose and lipid metabolism. The foundation of this review is the ability of enteric nematode infections to improve obesity-induced type 2 diabetes and the metabolic syndrome, which are significant health issues in developed areas. It considers the impact of nutrition and specific nutritional deficiencies, which are occur in both undeveloped and developed areas, on the host’s ability mount a protective immune response against parasitic nematodes. There are a number of proposed mechanisms by which parasitic nematodes can impact metabolism including effects gastrointestinal hormones, altering epithelial function, and changing the number and/or phenotype of immune cells in metabolic tissues. Nematodes can also exert their beneficial effects through Th2 cytokines that activate the transcription factor STAT6, which upregulates genes that regulate glucose and lipid metabolism.
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影响因子：
24.5
作者：
Depoortere, Inge
通讯作者：
Depoortere, Inge
影响因子：
4.8
作者：
Burk, Raymond F.;Hill, Kristina E.;Zhang, Wanqi
通讯作者：
Zhang, Wanqi
影响因子：
30.5
作者：
Chang CH;Pearce EL
通讯作者：
Pearce EL
影响因子：
24.3
作者：
Dittrich, A. M.;Meyer, H-A.;Hamelmann, E.
通讯作者：
Hamelmann, E.
DOI：
10.1038/ijo.2015.52
发表时间：
2015-08
期刊：
International journal of obesity (2005)
影响因子：
--
作者：
Darkhal P;Gao M;Ma Y;Liu D
通讯作者：
Liu D