Stimulating Memory: Reviewing Interventions Using Repetitive Transcranial Magnetic Stimulation to Enhance or Restore Memory Abilities.
Stimulating Memory: Reviewing Interventions Using Repetitive Transcranial Magnetic Stimulation to Enhance or Restore Memory Abilities.
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DOI：
10.3390/brainsci11101283
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发表时间：
2021-09-28
期刊：
影响因子：
3.3
通讯作者：
Warren DE
中科院分区：
文献类型：
--
作者：
Phipps CJ;Murman DL;Warren DE
人类记忆系统是不完美的记录设备，受年龄和疾病的影响，但最近的研究结果表明，这些系统的功能可以通过使用非侵入性脑刺激（如重复经颅磁刺激）的干预来修改。这些rTMS干预的转化潜力是明确的：记忆问题是与健康老龄化相关的最常见的认知问题，而阿尔茨海默病等病理状况通常与记忆的严重缺陷有关。改善记忆或治疗记忆丧失的疗法可以提高独立性，同时降低公共卫生系统的成本。尽管这一承诺，几个重要因素限制了rTMS干预记忆的普遍性和翻译潜力。方案设计、rTMS参数和结果测量的异质性对解释和再现性提出了重大挑战。然而，认知神经科学的最新进展，包括rTMS方法和功能性脑网络的最新见解，可能会提供必要的方法学工具，设计新的干预性研究，增强实验的严谨性，提高重现性，并更大的可能性，成功地转化为临床环境。在这篇综述中，我们首先讨论了目前的状态与rTMS的记忆调制的文献，然后在认知神经科学的发展是相关的rTMS干预措施提供评论，最后关闭提供了几个建议，为未来的调查设计使用rTMS来调节人类的记忆性能。
Human memory systems are imperfect recording devices that are affected by age and disease, but recent findings suggest that the functionality of these systems may be modifiable through interventions using non-invasive brain stimulation such as repetitive transcranial magnetic stimulation (rTMS). The translational potential of these rTMS interventions is clear: memory problems are the most common cognitive complaint associated with healthy aging, while pathological conditions such as Alzheimer’s disease are often associated with severe deficits in memory. Therapies to improve memory or treat memory loss could enhance independence while reducing costs for public health systems. Despite this promise, several important factors limit the generalizability and translational potential of rTMS interventions for memory. Heterogeneity of protocol design, rTMS parameters, and outcome measures present significant challenges to interpretation and reproducibility. However, recent advances in cognitive neuroscience, including rTMS approaches and recent insights regarding functional brain networks, may offer methodological tools necessary to design new interventional studies with enhanced experimental rigor, improved reproducibility, and greater likelihood of successful translation to clinical settings. In this review, we first discuss the current state of the literature on memory modulation with rTMS, then offer a commentary on developments in cognitive neuroscience that are relevant to rTMS interventions, and finally close by offering several recommendations for the design of future investigations using rTMS to modulate human memory performance.
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影响因子：
3.5
作者：
Berryhill ME
通讯作者：
Berryhill ME
影响因子：
3.4
作者：
Addicott, Merideth A.;Luber, Bruce;Appelbaum, Lawrence Gregory
通讯作者：
Appelbaum, Lawrence Gregory
DOI：
10.1016/j.cortex.2012.05.022
发表时间：
2013-05
期刊：
Cortex; a journal devoted to the study of the nervous system and behavior
影响因子：
--
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
3.7
作者：
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通讯作者：
Appelbaum, L. G.