antiSMASH 7.0: new and improved predictions for detection, regulation, chemical structures and visualisation.
antiSMASH 7.0: new and improved predictions for detection, regulation, chemical structures and visualisation.
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DOI：
10.1093/nar/gkad344
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发表时间：
2023-07-05
影响因子：
14.9
通讯作者：
Weber, Tilmann
中科院分区：
文献类型：
--
作者：
Blin, Kai;Shaw, Simon;Augustijn, Hannah E.;Reitz, Zachary L.;Biermann, Friederike;Alanjary, Mohammad;Fetter, Artem;Terlouw, Barbara R.;Metcalf, William W.;Helfrich, Eric J. N.;van Wezel, Gilles P.;Medema, Marnix H.;Weber, Tilmann
微生物产生小的生物活性化合物作为其次级或专门代谢的一部分。通常，这些代谢物具有抗微生物、抗癌、抗真菌、抗病毒或其他生物活性，因此在医学和农业应用中发挥重要作用。在过去的十年中，基因组挖掘已成为一种广泛使用的方法来探索，访问和分析这些化合物的可用生物多样性。自2011年以来，“抗生素和次级代谢物分析外壳-antiSMASH”（https：//antismash.secondarymetabolites.org/）一直支持研究人员进行微生物基因组挖掘任务，既可以作为免费使用的Web服务器，也可以作为OSI批准的开源许可证下的独立工具。它是目前最广泛使用的工具，用于检测和表征古细菌，细菌和真菌中的生物合成基因簇（BGC）。在这里，我们介绍了antiSMASH的更新版本7。antiSMASH 7将支持的簇类型从71种增加到81种，并在化学结构预测、酶组装线可视化和基因簇调控等领域进行了改进。antiSMASH 7将支持的簇类型数量从71种增加到81种，并在化学结构预测、酶组装线可视化和基因簇调节领域进行了改进。
Microorganisms produce small bioactive compounds as part of their secondary or specialised metabolism. Often, such metabolites have antimicrobial, anticancer, antifungal, antiviral or other bio-activities and thus play an important role for applications in medicine and agriculture. In the past decade, genome mining has become a widely-used method to explore, access, and analyse the available biodiversity of these compounds. Since 2011, the ‘antibiotics and secondary metabolite analysis shell—antiSMASH’ (https://antismash.secondarymetabolites.org/) has supported researchers in their microbial genome mining tasks, both as a free to use web server and as a standalone tool under an OSI-approved open source licence. It is currently the most widely used tool for detecting and characterising biosynthetic gene clusters (BGCs) in archaea, bacteria, and fungi. Here, we present the updated version 7 of antiSMASH. antiSMASH 7 increases the number of supported cluster types from 71 to 81, as well as containing improvements in the areas of chemical structure prediction, enzymatic assembly-line visualisation and gene cluster regulation. antiSMASH 7 increases the number of supported cluster types from 71 to 81, as well as containing improvements in the areas of chemical structure prediction, enzymatic assembly-line visualisation and gene cluster regulation.
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影响因子：
14.9
作者：
Mistry J;Chuguransky S;Williams L;Qureshi M;Salazar GA;Sonnhammer ELL;Tosatto SCE;Paladin L;Raj S;Richardson LJ;Finn RD;Bateman A
通讯作者：
Bateman A
影响因子：
9.2
作者：
Kautsar SA;van der Hooft JJJ;de Ridder D;Medema MH
通讯作者：
Medema MH
影响因子：
14.9
作者：
Haft DH;Selengut JD;Richter RA;Harkins D;Basu MK;Beck E
通讯作者：
Beck E
影响因子：
9.5
作者：
Blin K;Kim HU;Medema MH;Weber T
通讯作者：
Weber T
影响因子：
14.8
作者：
Medema, Marnix H.;Fischbach, Michael A.
通讯作者：
Fischbach, Michael A.