History repeats itself: Role of characterizing flavors on nicotine use and abuse.

History repeats itself: Role of characterizing flavors on nicotine use and abuse.
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DOI:
10.1016/j.neuropharm.2020.108162
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发表时间:
2020-10-15
期刊:
影响因子:
4.7
通讯作者:
De Biasi M
De Biasi M
中科院分区:
医学2区
文献类型:
--
作者:
Patten T;De Biasi M

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近年来,电子烟的受欢迎程度直线上升,大多数电子烟使用者都使用调味电子烟产品。在青少年中,调味电子烟的消费量超过了可燃香烟和其他烟草产品,他们特别容易对尼古丁产生依赖。自17世纪以来,烟草行业一直在使用香料,但电子烟行业使用香料来制造具有“特征”口味(即烟草或薄荷醇以外的口味)的产品,引发了一场公共卫生辩论。这篇综述提出了一种可能性,即风味的特征使尼古丁更有吸引力、更有回报、更容易上瘾。它还讨论了临床前和临床研究可以提高我们对口味可能改变尼古丁奖励和强化的机制的理解的方法。这篇文章是“尼古丁神经药理学的当代进展”特刊的一部分。
The popularity of e-cigarettes has skyrocketed in recent years, and most vapers use flavored e-cigarette products. Consumption of flavored e-cigarettes exceeds that of combustible cigarettes and other tobacco products among adolescents, who are particularly vulnerable to becoming nicotine dependent. Flavorings have been used by the tobacco industry since the 17th century, but the use of flavors by the e-cigarette industry to create products with “characterizing” flavors (i.e. flavors other than tobacco or menthol) has sparked a public health debate. This review addresses the possibility that characterizing flavors make nicotine more appealing, rewarding and addictive. It also discusses ways in which preclinical and clinical studies could improve our understanding of the mechanisms by which flavors may alter nicotine reward and reinforcement. This article is part of the special issue on ‘Contemporary Advances in Nicotine Neuropharmacology’.
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