Insights into cerebellar development and connectivity.
Insights into cerebellar development and connectivity.
复制标题
对小脑发展和连通性的见解。
DOI：
10.1016/j.neulet.2018.05.013
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发表时间：
2019-01-01
影响因子：
2.5
通讯作者：
Sillitoe RV
中科院分区：
文献类型：
--
作者：
Beckinghausen J;Sillitoe RV
小脑在控制运动功能，如协调、平衡、姿势和熟练学习等方面具有公认的作用。越来越多的证据表明，它也可能在认知和情感等非运动功能中发挥关键作用。因此，小脑缺陷与包括共济失调、肌张力障碍震颤、精神分裂症、阅读障碍和自闭症谱系障碍在内的一系列疾病有关就不足为奇了。有趣的是，一个看似统一的电路，经常被描述为“简单”，应该执行所有这些行为。对小脑回路发展的分析表明，这种描述大大低估了小脑的复杂性。小脑实际上是高度图案化的，围绕着一系列副矢状面条纹和横向区进行组织。这种地形结构将所有小脑回路划分为功能模块，这些功能模块被认为可以增强小脑依赖行为期间的处理能力。可以说，小脑地形最显著的特征是产生它们的发育过程。这篇综述关注的是协调小脑模式的遗传和细胞机制。我们把重点放在浦肯野细胞如何控制小脑电路组装的各个方面。利用这个模型，我们讨论了浦肯野细胞中“斑马样”模式如何塑造小脑的证据，特定的遗传线索如何介导这一过程，以及活动如何将这些模式提炼成能够执行各种功能的成人图谱。我们还将讨论浦肯野细胞模式缺陷如何影响神经系统疾病的发病机制。
The cerebellum has a well-established role in controlling motor functions such coordination, balance, posture, and skilled learning. There is mounting evidence that it might also play a critical role in non-motor functions such as cognition and emotion. It is therefore not surprising that cerebellar deficits are associated with a wide array of diseases including ataxia, dystonia tremor, schizophrenia, dyslexia, and autism spectrum disorder. What is intriguing is that a seemingly uniform circuit that is often described as being “simple” should carry out all of these behaviors. Analyses of how cerebellar circuits develop have revealed that such descriptions massively underestimate the complexity of the cerebellum. The cerebellum is in fact highly patterned and organized around a series of parasagittal stripes and transverse zones. This topographic architecture partitions all cerebellar circuits into functional modules that are thought to enhance processing power during cerebellar dependent behaviors. What are arguably the most remarkable features of cerebellar topography are the developmental processes that produce them. This review is concerned with the genetic and cellular mechanisms that orchestrate cerebellar patterning. We place a major focus on how Purkinje cells control all aspects of cerebellar circuit assembly. Using this model, we discuss evidence for how “zebra-like” patterns in Purkinje cells sculpt the cerebellum, how specific genetic cues mediate the process, and how activity refines the patterns into an adult map that is capable of executing various functions. We will also discuss how defective Purkinje cell patterning might impact the pathogenesis of neurological conditions.
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影响因子：
3.5
作者：
Baumann, Oliver;Borra, Ronald J.;Bower, James M.;Cullen, Kathleen E.;Habas, Christophe;Ivry, Richard B.;Leggio, Maria;Mattingley, Jason B.;Molinari, Marco;Moulton, Eric A.;Paulin, Michael G.;Pavlova, Marina A.;Schmahmann, Jeremy D.;Sokolov, Arseny A.
通讯作者：
Sokolov, Arseny A.
影响因子：
3.5
作者：
Armstrong, Carol L.;Duffin, Catherine A.;Vogel, Michael William
通讯作者：
Vogel, Michael William
DOI：
10.1073/pnas.0910786107
发表时间：
2010-06-08
影响因子：
11.1
作者：
Chizhikov, Victor V.;Lindgren, Anne G.;Millen, Kathleen J.
通讯作者：
Millen, Kathleen J.
影响因子：
64.8
作者：
BenArie, N;Bellen, HJ;Zoghbi, HY
通讯作者：
Zoghbi, HY
影响因子：
2.5
作者：
BROCHU, G;MALER, L;HAWKES, R
通讯作者：
HAWKES, R