Associations between Maternal Cadmium Exposure with Risk of Preterm Birth and Low after Birth Weight Effect of Mediterranean Diet Adherence on Affected Prenatal Outcomes.
Associations between Maternal Cadmium Exposure with Risk of Preterm Birth and Low after Birth Weight Effect of Mediterranean Diet Adherence on Affected Prenatal Outcomes.
复制标题
DOI：
10.3390/toxics8040090
复制
发表时间：
2020-10-20
期刊：
影响因子：
4.6
通讯作者：
Hoyo C
中科院分区：
文献类型：
--
作者：
Gonzalez-Nahm S;Nihlani K;S House J;L Maguire R;G Skinner H;Hoyo C
产前非职业性镉暴露与不良出生结局相关。摄入必需金属，如铁和硒，可以减轻镉暴露的影响。然而，在高水平下，这些金属可能是有毒的。富含这些金属的饮食模式的作用研究较少。我们在一个包含185对母婴的队列中使用线性和逻辑回归来评估妊娠期间地中海饮食模式是否改变了产前镉暴露与（1）出生体重和（2）早产之间的关联。我们发现孕期镉暴露增加与出生体重降低有关（β = − 210.4; 95% CI：− 332.0，− 88.8; p = 0.008）和早产（OR = 0.11; 95% CI：0.01，0.72; p = 0.04）;然而，这些关联在报告高度坚持地中海饮食的女性所生的后代中是相当的，（β = − 274.95; 95%CI：− 701.17，151.26; p = 0.20）和低依从性（β = − 64.76; 95%CI：− 359.90，230.37; p = 0.66）。虽然小样本量限制了推断，但我们的研究结果表明，坚持地中海饮食模式可能不会减轻镉暴露的影响。鉴于镉靶向的多个器官及其缓慢的排泄率，需要更大规模的研究来澄清这些发现。
Prenatal cadmium exposure at non-occupational levels has been associated with poor birth outcomes. The intake of essential metals, such as iron and selenium, may mitigate cadmium exposure effects. However, at high levels, these metals can be toxic. The role of dietary patterns rich in these metals is less studied. We used a linear and logistic regression in a cohort of 185 mother–infant pairs to assess if a Mediterranean diet pattern during pregnancy modified the associations between prenatal cadmium exposure and (1) birth weight and (2) preterm birth. We found that increased cadmium exposure during pregnancy was associated with lower birth weight (β = −210.4; 95% CI: −332.0, −88.8; p = 0.008) and preterm birth (OR = 0.11; 95% CI: 0.01, 0.72; p = 0.04); however, these associations were comparable in offspring born to women reporting high adherence to a Mediterranean diet (β = −274.95; 95% CI: −701.17, 151.26; p = 0.20) and those with low adherence (β = −64.76; 95% CI: −359.90, 230.37; p = 0.66). While the small sample size limits inference, our findings suggest that adherence to a Mediterranean dietary pattern may not mitigate cadmium exposure effects. Given the multiple organs targeted by cadmium and its slow excretion rate, larger studies are required to clarify these findings.
登录
查看更多内容
影响因子：
5.9
作者：
Mijatovic-Vukas J;Capling L;Cheng S;Stamatakis E;Louie J;Cheung NW;Markovic T;Ross G;Senior A;Brand-Miller JC;Flood VM
通讯作者：
Flood VM
影响因子：
3.6
作者：
Chatzi, Leda;Mendez, Michelle;Sunyer, Jordi
通讯作者：
Sunyer, Jordi
影响因子：
2.9
作者：
Beam, Andrew L.;Fried, Inbar;Armstrong, Joanne
通讯作者：
Armstrong, Joanne
影响因子：
5.9
作者：
Kim, Kijoon;Melough, Melissa M.;Chun, Ock K.
通讯作者：
Chun, Ock K.
DOI：
10.1080/14767058.2017.1399120
发表时间：
2019-04-03
影响因子：
1.8
作者：
Parlapani, Elisavet;Agakidis, Charalampos;Diamanti, Elisavet
通讯作者：
Diamanti, Elisavet