Importance of the locus coeruleus-norepinephrine system in sleep-wake regulation: Implications for aging and Alzheimer's disease.
Importance of the locus coeruleus-norepinephrine system in sleep-wake regulation: Implications for aging and Alzheimer's disease.
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DOI：
10.1016/j.smrv.2022.101592
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发表时间：
2022-04
影响因子：
10.5
通讯作者：
Jacobs, Heidi I. L.
中科院分区：
文献类型：
--
作者：
Van Egroo, Maxime;Koshmanova, Ekaterina;Vandewalle, Gilles;Jacobs, Heidi I. L.
关键词：
50年前，开创性的研究将脑干蓝斑（LC）去甲肾上腺素（NE）系统定位为觉醒和睡眠调节的关键底物，最近，由于LC结构和功能的精确研究和实验调节的方法学进步，这一图像得到了详细阐述。这篇综述提出并讨论了支持LC- ne系统在不同层次的睡眠-觉醒组织中的主要作用的研究结果，从它参与睡眠-觉醒周期的整体架构到它与睡眠微观结构的关联，同时考虑了LC周围复杂的神经解剖学。鉴于LC-NE系统处于阿尔茨海默病（AD）的睡眠-觉醒失调和初始病理生理过程的交叉点所占据的特殊地位，我们通过研究人类衰老中LC-NE介导的睡眠-觉醒改变与AD之间的关系来总结。我们进一步提出了几个研究观点，可以支持LC-NE系统作为识别阿尔茨海默病临床前阶段高危个体和开发新型预防干预措施的有希望的靶点。
Five decades ago, seminal studies positioned the brainstem locus coeruleus (LC) norepinephrine (NE) system as a key substrate for the regulation of wakefulness and sleep, and this picture has recently been elaborated thanks to methodological advances in the precise investigation and experimental modulation of LC structure and functions. This review presents and discusses findings that support the major role of the LC-NE system at different levels of sleep-wake organization, ranging from its involvement in the overall architecture of the sleep-wake cycle to its associations with sleep microstructure, while accounting for the intricate neuroanatomy surrounding the LC. Given the particular position held by the LC-NE system by being at the intersection of sleep-wake dysregulation and initial pathophysiological processes of Alzheimer’s disease (AD), we conclude by examining emerging opportunities to investigate LC-NE mediated relationships between sleep-wake alteration and AD in human aging. We further propose several research perspectives that could support the LC-NE system as a promising target for the identification of at-risk individuals in the preclinical stages of AD, and for the development of novel preventive interventions.
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DOI：
10.1073/pnas.1202526109
发表时间：
2012-09-25
影响因子：
11.1
作者：
Carter, Matthew E.;Brill, Julia;de Lecea, Luis
通讯作者：
de Lecea, Luis
影响因子：
3.3
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Mallick, Birendra Nath
影响因子：
5.3
作者：
Chandler, Dan J.;Jensen, Patricia;Totah, Nelson K.
通讯作者：
Totah, Nelson K.
影响因子：
5.2
作者：
Bretherton, Beatrice;Atkinson, Lucy;Deuchars, Jim
通讯作者：
Deuchars, Jim