Low Turnover Renal Osteodystrophy With Abnormal Bone Quality and Vascular Calcification in Patients With Mild-to-Moderate CKD.
Low Turnover Renal Osteodystrophy With Abnormal Bone Quality and Vascular Calcification in Patients With Mild-to-Moderate CKD.
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DOI：
10.1016/j.ekir.2022.02.022
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发表时间：
2022-05
影响因子：
6
通讯作者：
Malluche, Hartmut H.
中科院分区：
文献类型：
--
作者：
El-Husseini, Amr;Abdalbary, Mohamed;Lima, Florence;Issa, Mohamed;Ahmed, Mohamed-Tarek;Winkler, Michael;Srour, Habib;Davenport, Daniel;Wang, Guodong;Faugere, Marie-Claude;Malluche, Hartmut H.
关键词：
Limited information is available on renal osteodystrophy (ROD) and vascular calcification (VC) during early chronic kidney disease (CKD). This study was designed to evaluate ROD and VC in 32 patients with CKD stages II to IV. Patients underwent dual-energy X-ray absorptiometry (DXA) for assessment of bone mineral density (BMD) and trabecular bone score (TBS), thoracic computed tomography for VC scoring using the Agatston method, and anterior iliac crest bone biopsy for mineralized bone histology, histomorphometry, and Fourier transform infrared spectroscopy (FTIR). Classical and novel bone markers were determined in the blood. Mean estimated glomerular filtration rate (eGFR) was 44 ± 16 ml/min per 1.73 m2. Of the patients, 84% had low bone turnover. In Whites, eGFR correlated negatively with the turnover parameter activation frequency (Ac.f) (r −0.48, P = 0.019) and with parameters of bone formation. Most patients had VC (>80%) which correlated positively with levels of phosphorus, c-terminal fibroblast growth factor-23, and activin. Aortic calcifications (ACs) correlated negatively with bone formation rate (BFR) and Ac.f (rho −0.62, −0.61, P < 0.001). TBS correlated negatively with coronary calcification (rho −0.42, P = 0.019) and AC (rho −0.57, P = 0.001). These relationships remained after adjustment of age. The mineral-to-matrix ratio, an FTIR metric reflecting bone quality, was negatively related to Ac.f and positively related to AC. Low bone turnover and VC are predominant in early stages of CKD. This is the first study demonstrating mineral abnormalities indicating reduced bone quality in these stages of CKD.
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DOI：
10.1002/jbmr.2759
发表时间：
2016-05
期刊：
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
影响因子：
--
作者：
Boskey AL;Donnelly E;Boskey E;Spevak L;Ma Y;Zhang W;Lappe J;Recker RR
通讯作者：
Recker RR
影响因子：
24
作者：
Chen J;Budoff MJ;Reilly MP;Yang W;Rosas SE;Rahman M;Zhang X;Roy JA;Lustigova E;Nessel L;Ford V;Raj D;Porter AC;Soliman EZ;Wright JT Jr;Wolf M;He J;CRIC Investigators
通讯作者：
CRIC Investigators
影响因子：
4.1
作者：
Aleksova, Jasna;Kurniawan, Samantha;Elder, Grahame J.
通讯作者：
Elder, Grahame J.
影响因子：
6.2
作者：
Gourion-Arsiquaud, Samuel;Faibish, Dan;Boskey, Adele L.
通讯作者：
Boskey, Adele L.
影响因子：
6.2
作者：
Fahrleitner-Pammer, Astrid;Herberth, Johann;Malluche, Hartmut H.
通讯作者：
Malluche, Hartmut H.