Lithocholic Acid Improves the Survival of Drosophila Melanogaster
Lithocholic Acid Improves the Survival of Drosophila Melanogaster
复制标题
石胆酸提高果蝇的存活率
DOI：
10.1002/mnfr.201800424
复制
发表时间：
2018
影响因子：
5.2
通讯作者：
Wagner AE
中科院分区：
文献类型：
--
作者：
Staats S;Rimbach G;Kuenstner A;Graspeuntner S;Rupp J;Busch H;Sina C;Ipharraguerre IR;Wagner AE
范围初级胆汁酸在肝脏中产生，而次级胆汁酸，如石胆酸（LCA），由肠道细菌从逃避回肠吸收的初级胆汁酸产生。除了众所周知的功能作为洗涤剂在脂质消化，胆汁酸是重要的信号分子介导的影响宿主的metabolic.Methods和resultsFruit flies（Drosophila melanogaster）补充50 μmol L-1 LCA无论是30天或在其整个生命周期。与未处理的对照果蝇相比，LCA补充导致平均寿命（+12天）、中值寿命（+10天）和最大寿命（+11天）的显著诱导。这种寿命延长伴随着spargel（srl）的诱导，spargel是哺乳动物PPAR-γ共激活因子1α（PGC 1 α）的果蝇同系物。在野生型苍蝇，抗生素的管理废除LCA介导的寿命诱导以及srl.ConclusionIt的上调表明，二级胆汁酸LCA显着诱导的平均值，中位数，和最大的生存在D.黑腹果蝇。我们的数据表明，除了PGC 1 α-homologsrl的上调外，肠道微生物群结构或代谢的未识别改变有助于LCA介导的长寿效应。
ScopePrimary bile acids are produced in the liver, whereas secondary bile acids, such as lithocholic acid (LCA), are generated by gut bacteria from primary bile acids that escape the ileal absorption. Besides their well‐known function as detergents in lipid digestion, bile acids are important signaling molecules mediating effects on the host's metabolism.Methods and resultsFruit flies (Drosophila melanogaster) are supplemented with 50 μmol L–1LCA either for 30 days or throughout their lifetime. LCA supplementation results in a significant induction of the mean (+12 days), median (+10 days), and maximum lifespan (+ 11 days) in comparison to untreated control flies. This lifespan extension is accompanied by an induction of spargel (srl), the fly homolog of mammalian PPAR‐γ co‐activator 1α (PGC1α). In wild‐type flies, the administration of antibiotics abrogates both the LCA‐mediated lifespan induction as well as the upregulation ofsrl.ConclusionIt is shown that the secondary bile acid LCA significantly induces the mean, the median, and the maximum survival inD. melanogaster. Our data suggest that besides an upregulation of the PGC1α‐homologsrl, unidentified alterations in the structure or metabolism of the gut microbiota contribute to the longevity effect mediated by LCA.
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影响因子：
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