Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population.
Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population.
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DOI：
10.1016/j.cmet.2014.02.006
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发表时间：
2014-03-04
期刊：
影响因子：
29
通讯作者：
Longo VD
中科院分区：
文献类型：
--
作者：
Levine ME;Suarez JA;Brandhorst S;Balasubramanian P;Cheng CW;Madia F;Fontana L;Mirisola MG;Guevara-Aguirre J;Wan J;Passarino G;Kennedy BK;Wei M;Cohen P;Crimmins EM;Longo VD
具有生长激素受体/IGF-1缺陷的小鼠和人类显示出与年龄相关的疾病的显著减少。由于蛋白质限制降低了GHR-IGF-1活性，我们研究了蛋白质摄入量和死亡率之间的联系。在18年随访期间，报告高蛋白质摄入的50-65岁受访者（n= 6，381）的总体死亡率增加了75%，癌症和糖尿病死亡率增加了4倍。如果蛋白质来源是植物性的，这些关联就会被消除或减弱。相反，在65岁以上的受访者中，高蛋白质摄入量与癌症和总体死亡率的降低有关。小鼠研究证实了高蛋白摄入量和GHR-IGF-1轴对乳腺癌和黑色素瘤的发病率和进展的影响，以及低蛋白饮食对老年人的不利影响。这些结果表明，在中年期间低蛋白质摄入量，然后在老年受试者中适度摄入蛋白质，可能会优化健康和长寿。
Mice and humans with Growth Hormone Receptor/IGF-1 deficiencies display major reductions in age-related diseases. Because protein restriction reduces GHR-IGF-1 activity, we examined links between protein intake and mortality. Respondents (n=6,381) aged 50–65 reporting high protein intake had a 75% increase in overall mortality and a 4-fold increase in cancer and diabetes mortality during an 18 year follow up period. These associations were either abolished or attenuated if the source of proteins was plant-based. Conversely, in respondents over age 65, high protein intake was associated with reduced cancer and overall mortality. Mouse studies confirmed the effect of high protein intake and the GHR-IGF-1 axis on the incidence and progression of breast and melanoma tumors, and also the detrimental effects of a low protein diet in the very old. These results suggest that low protein intake during middle age followed by moderate protein consumption in old subjects may optimize healthspan and longevity.
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影响因子：
7.8
作者：
Fontana L;Weiss EP;Villareal DT;Klein S;Holloszy JO
通讯作者：
Holloszy JO
DOI：
10.1126/science.1173635
发表时间：
2009-07-10
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Colman RJ;Anderson RM;Johnson SC;Kastman EK;Kosmatka KJ;Beasley TM;Allison DB;Cruzen C;Simmons HA;Kemnitz JW;Weindruch R
通讯作者：
Weindruch R
DOI：
10.1093/gerona/62.4.352
发表时间：
2007-04-01
影响因子：
5.1
作者：
Ayala, Victoria;Naudi, Alba;Pamplona, Reinald
通讯作者：
Pamplona, Reinald
影响因子：
4.2
作者：
Blanton, Cynthia A.;Moshfegh, Alanna J.;Kretsch, Mary J.
通讯作者：
Kretsch, Mary J.
DOI：
10.1093/geronj/45.4.b129
发表时间：
1990-07-01
期刊：
JOURNALS OF GERONTOLOGY
影响因子：
--
作者：
CHEN, TS;CURRIER, GJ;WABNER, CL
通讯作者：
WABNER, CL