New-onset vegetarian diet shows differences in fatty acid metabolites in European American and African American women.
New-onset vegetarian diet shows differences in fatty acid metabolites in European American and African American women.
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DOI：
10.1016/j.numecd.2021.05.013
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发表时间：
2021-07-22
影响因子：
3.9
通讯作者：
Silver, Heidi J.
中科院分区：
文献类型：
--
作者：
Wang, Naomi C.;Bagheri, Minoo;Olszewski, Timothy;Friese, Katie A.;Smith, Holly M.;Robles, Michelle E.;Wang, Chuan;Brooks, Andrew;Bordenstein, Seth R.;Ferguson, Jane F.;Silver, Heidi J.
以动物为基础的西方饮食中消耗的脂肪类型，通常富含饱和脂肪棕榈酸酯，与心脏代谢性疾病的风险有关。相比之下，最丰富的单不饱和脂肪和多不饱和脂肪，在素食或植物性饮食中更具代表性，增强了较少的有害影响。这项研究确定了从杂食性饮食转变为素食饮食时，血浆和尿液代谢物的差异，包括与脂肪酸利用有关的代谢物。38名欧洲人(EA)和非裔美国人(AA)杂食性女性的前瞻性队列在年龄(25.7±5.3岁)和BMI(22.4±1.9 kg/m2)方面匹配。干预前样本是在受试者食用习惯性动物性饮食的同时采集的。代谢物的变化通过超高效液相色谱-串联质谱仪(代谢公司)进行评估。在完成了范德比尔特新陈代谢厨房提供的为期四天的新型素食饮食后。观察到了几种饮食来源的代谢物的变化，包括来自大豆食物代谢的化合物增加，以及黄嘌呤和组氨酸的代谢物减少。饱和脂肪酸、单不饱和脂肪酸和多不饱和脂肪酸的代谢物发生了显著变化，而EA和AA女性之间血浆酰肉碱浓度的变化也有显著差异，这反映了脂肪酸氧化(而不是储存)的完整性。这些数据表明，通过采用素食(植物性)饮食，脂肪酸代谢(氧化与储存)的改善可能会迅速促进能量平衡的关键因素。必须了解饮食干预措施的反应机制差异，以便有效地预防肥胖和心脏代谢性疾病在人群亚群中的广泛发展，例如再生障碍性贫血妇女。
The type of fat consumed in animal-based western diets, typically rich in the saturated fat palmitate, has been implicated in cardiometabolic disease risk. In contrast, the most abundant mono- and polyunsaturated fats, more typical in a vegetarian or plant-based diet, potentiate less deleterious effects. This study determined differences in plasma and urine metabolites when switching from omnivorous to vegetarian diet, including metabolites involved in fatty acid utilization. A prospective cohort of 38 European (EA) and African American (AA) omnivorous females were matched by age (25.7±5.3y) and BMI (22.4±1.9kg/m2). Pre-intervention samples were collected while subjects consumed habitual animal-based diet. Changes in metabolites were assessed by ultra-high-performance liquid chromatography-tandem mass spectroscopy (Metabolon, Inc.) upon completing four days of novel vegetarian diet provided by the Vanderbilt Metabolic Kitchen. Changes in several diet-derived metabolites were observed, including increases in compounds derived from soy food metabolism along with decreases in metabolites of xanthine and histidine. Significant changes occurred in metabolites of saturated, monounsaturated and polyunsaturated fatty acids along with significant differences between EA and AA women in changes in plasma concentrations of acylcarnitines, which reflect the completeness of fatty acid oxidation (versus storage). These data suggest improvements in fatty acid metabolism (oxidation vs storage), a key factor in energy homeostasis, may be promoted rapidly by adoption of a vegetarian (plant-based) diet. Mechanistic differences in response to diet interventions must be understood to effectively provide protection against the widespread development of obesity and cardiometabolic disease in population subgroups, such as AA women.
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影响因子：
5.2
作者：
Kochlik B;Gerbracht C;Grune T;Weber D
通讯作者：
Weber D
DOI：
10.1073/pnas.4.12.370
发表时间：
1918-01-01
影响因子：
11.1
作者：
Harris, JA;Benedict, FG
通讯作者：
Benedict, FG
影响因子：
3.5
作者：
Kwok, Chun Shing;Umar, Saadia;Loke, Yoon K.
通讯作者：
Loke, Yoon K.
影响因子：
5.9
作者：
Kahleova H;Levin S;Barnard N
通讯作者：
Barnard N
影响因子：
4.3
作者：
Andersen, Maj-Britt Schmidt;Kristensen, Mette;Dragsted, Lars
通讯作者：
Dragsted, Lars