The Influence of Dietary Habits and Meat Consumption on Plasma 3-Methylhistidine-A Potential Marker for Muscle Protein Turnover.
The Influence of Dietary Habits and Meat Consumption on Plasma 3-Methylhistidine-A Potential Marker for Muscle Protein Turnover.
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DOI：
10.1002/mnfr.201701062
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发表时间：
2018-05
影响因子：
5.2
通讯作者：
Weber D
中科院分区：
文献类型：
--
作者：
Kochlik B;Gerbracht C;Grune T;Weber D
3-甲基组氨酸（3-MH）作为肌肉蛋白质转换的潜在生物标志物受到肉类摄入的影响，但关于肉类对血浆3-MH影响的数据很少。我们确定了血浆3-MH、1-甲基组氨酸（1-MH）和肌酐与饮食习惯的相关性，并评估了无肉期间单次白色肉干预的影响。分析了健康年轻杂食动物（n = 19）和素食者（n = 16）的血浆3-MH，1-MH和肌酐浓度，以及人体测量学，身体成分，握力和营养方面的数据。在基线测量后，杂食动物坚持无肉饮食6天，并在第4天接受规定的鸡胸肉给药。在基线时，杂食者的血浆3-MH和1-MH浓度高于素食者。在杂食动物中，白色肉给药导致血浆3-MH略微增加。在摄入白色肉后24 h内，升高的3-MH浓度显著下降。血浆中的1-MH浓度似乎适合于显示（白色）肉类消费及其对3-MH血浆浓度的影响。如果受试者在过去24小时内未食用肉类，则血浆中的3-MH可用作肌肉蛋白质转换的生物标志物。
3‐Methylhistidine (3‐MH) as a potential biomarker for muscle protein turnover is influenced by meat intake but data on the impact of meat on plasma 3‐MH are scarce. We determined the association of plasma 3‐MH, 1‐methylhistidine (1‐MH), and creatinine with dietary habits and assessed the impact of a single white meat intervention during a meat‐free period. Plasma 3‐MH, 1‐MH, and creatinine concentrations of healthy young omnivores (n = 19) and vegetarians (n = 16) were analyzed together with data on anthropometry, body composition, grip strength, and nutrition. After baseline measurements omnivores adhered to a meat‐free diet for 6 days and received a defined administration of chicken breast on day four. At baseline, omnivores had higher plasma 3‐MH and 1‐MH concentrations than vegetarians. White meat administration led to a slight increase in plasma 3‐MH in omnivores. The elevated 3‐MH concentrations significantly declined within 24 h after white meat intake. 1‐MH concentrations in plasma seem to be suitable to display (white) meat consumption and its influence on 3‐MH plasma concentration. 3‐MH in plasma may be used as a biomarker for muscle protein turnover if subjects have not consumed meat in the previous 24 h.
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影响因子：
9.8
作者：
LONG, CL;HAVERBERG, LN;GEIGER, JW
通讯作者：
GEIGER, JW
DOI：
10.1158/1055-9965.epi-11-0048
发表时间：
2011-06
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Cross AJ;Major JM;Sinha R
通讯作者：
Sinha R
DOI：
10.1016/0020-711x(93)90074-o
发表时间：
1993-09-01
期刊：
INTERNATIONAL JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
ABE, H;OKUMA, E;YOSHIUE, S
通讯作者：
YOSHIUE, S
影响因子：
11
作者：
MCKERAN, RO;HALLIDAY, D;ROYSTON, P
通讯作者：
ROYSTON, P
影响因子：
5
作者：
BUTLER, AR
通讯作者：
BUTLER, AR