High-speed whole-brain oximetry by golden-angle radial MRI.
High-speed whole-brain oximetry by golden-angle radial MRI.
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DOI：
10.1002/mrm.26666
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发表时间：
2018-01
影响因子：
3.3
通讯作者：
Wehrli FW
中科院分区：
文献类型：
--
作者：
Cao W;Chang YV;Englund EK;Song HK;Barhoum S;Rodgers ZB;Langham MC;Wehrli FW
为了确定全脑脑氧代谢率（CMRO 2），开发了一种基于径向编码的改进成像方法，称为“径向OxFlow”（rOxFlow），以同时定量引流静脉静脉血氧饱和度（SvO 2）和总脑血流量（tCBF）。为了评价rOxFlow序列的有效性和精确度，在使用rOxFlow和笛卡尔Ox-Flow（cOxFlow）序列进行重复屏气的范例期间对10名受试者进行了研究。假设动脉血氧饱和度为97%，根据OxFlow测量数据计算基线时的CMRO 2，并量化SvO 2和tCBF屏气反应。cOxFlow和rOxFlow的10名受试者的平均神经代谢-血管参数分别为：SvO 2（%）基线：64.6 ± 8.0 vs. 64.2 ± 6.6; SvO 2峰值：70.5 ± 8.5 vs. 72.6 ± 5.4; tCBF（mL/min/100 g）基线：39.2 ± 3.8 vs. 40.6 ± 8.0; tCBF峰值：53.2 ± 5.1 vs. 56.1 ±11.7; CMRO 2（μmol O2/min/100 g）基线：111.5 ± 26.8 vs. 120.1 ± 19.6。上述指标在序列间无显著性差异（p>0.05）。两种方法在测量的生理反应方面有很好的一致性。比较两者，rOxFlow提供了更高的时间分辨率和更大的重建灵活性，同时保持高SNR。
To determine whole-brain cerebral metabolic rate of oxygen (CMRO2), an improved imaging approach, based on radial encoding, termed ‘radial OxFlow’ (rOxFlow), was developed to simultaneously quantify draining vein venous oxygen saturation (SvO2) and total cerebral blood flow (tCBF). To evaluate the efficiency and precision of the rOxFlow sequence, 10 subjects were studied during a paradigm of repeated breath-holds with both rOxFlow and Cartesian Ox-Flow (cOxFlow) sequences. CMRO2 was calculated at baseline from OxFlow-measured data assuming an arterial O2 saturation of 97%, and the SvO2 and tCBF breath-hold responses were quantified. Average neurometabolic-vascular parameters across the ten subjects for cOxFlow and rOxFlow were, respectively: SvO2 (%) baseline: 64.6 ± 8.0 vs. 64.2 ± 6.6; SvO2 peak: 70.5 ± 8.5 vs. 72.6 ± 5.4; tCBF (mL/min/100g) baseline: 39.2 ± 3.8 vs. 40.6 ± 8.0; tCBF peak: 53.2 ± 5.1 vs. 56.1 ±11.7; CMRO2 (μmol O2/min/100g) baseline: 111.5 ± 26.8 vs. 120.1 ± 19.6. The above measures were not significantly different between sequences (p>0.05). There was good agreement between the two methods in terms of the physiologic responses measured. Comparing the two, rOxFlow provided higher temporal resolution and greater flexibility for reconstruction while maintaining high SNR.
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影响因子：
3.3
作者：
Feng, Li;Grimm, Robert;Block, Kai Tobias;Chandarana, Hersh;Kim, Sungheon;Xu, Jian;Axel, Leon;Sodickson, Daniel K.;Otazo, Ricardo
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6.3
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通讯作者：
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影响因子：
6.3
作者：
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