The Diagnostic Value Of Using 18F-Fluorodeoxyglucose Positron Emission Tomography To Differentiate Between Low- And High-Grade Meningioma
The Diagnostic Value Of Using 18F-Fluorodeoxyglucose Positron Emission Tomography To Differentiate Between Low- And High-Grade Meningioma
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18F-氟脱氧葡萄糖正电子发射断层扫描鉴别低级别和高级别脑膜瘤的诊断价值
DOI：
10.2147/cmar.s228129
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发表时间：
2019-10
影响因子：
3.3
通讯作者：
Ye Gong
中科院分区：
文献类型：
--
作者：
Lingyang Hua;Fengchun Hua;Hongda Zhu;Jiaojiao Deng;Daijun Wang;Shihai Luan;Hailiang Tang;Yihui Guan;Qing Xie;Ye Gong
目的本研究旨在评估18F氟脱氧葡萄糖正电子发射断层扫描（18F-FDG PET）在检测高级脑膜瘤并预测脑膜瘤手术后患者预后的潜在作用。病人和方法
Objective This study aims to evaluate the potential role of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) in detecting high-grade meningiomas and predicting the prognosis of patients after meningioma surgery. Patients and methods A total of 124 patients met the final inclusion criterion. Tumor to gray ratio (TGR) was compared with Ki-67 labeling index, and its correlations with pre-operative neurological function and treatment status were also evaluated. Receiver-operating characteristic (ROC) curve was drawn to determine a cut-off value which could discriminate meningioma of different grades. Prognostic factors including TGR were analyzed using Kaplan-Meier survival curve and cox proportional model. Results The TGR of higher World Health Organization (WHO) grade meningioma was significantly higher than that in lower grade (p < 0.001), and it was correlated with the Ki-67 labeling index (p < 0.001, r = 0.1545). The TGR of 1.30 was the best cutoff value for the detection of high grade (WHO grade II&III) meningioma from low grade (WHO grade I) according to ROC analysis, with a sensitivity of 61.5%, the specificity of 86.7%, and accuracy of 81.5%. The TGR (p < 0.001), treatment status (p = 0.035), tumor grade (p < 0.001) and Ki-67 labeling index (p < 0.001) were significantly associated with progression-free survival (PFS). Cox proportional hazards model demonstrated that TGR (p = 0.013) was an independent prognostic factor for PFS. Conclusion A high uptake of FDG was correlated with a more proliferative biological behavior and is a risk factor for tumor recurrence.
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DOI：
--
发表时间：
1994-08
期刊：
Nuklearmedizin. Nuclear medicine
影响因子：
--
作者：
U. Cremerius;E. Striepecke;W. Henn;J. Weis;M. Mull;B. Lippitz;J. Gilsbach;J. Schröder;K. Zang;A. Böcking
通讯作者：
U. Cremerius;E. Striepecke;W. Henn;J. Weis;M. Mull;B. Lippitz;J. Gilsbach;J. Schröder;K. Zang;A. Böcking
影响因子：
3.9
作者：
Potter M;Newport E;Morten KJ
通讯作者：
Morten KJ
影响因子：
15.9
作者：
Zhang, Adah S.;Ostrom, Quinn T.;Barnholtz-Sloan, Jill S.
通讯作者：
Barnholtz-Sloan, Jill S.
DOI：
10.1016/0895-6111(89)90079-7
发表时间：
1989
期刊：
Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
影响因子：
--
作者：
D. Jamieson;J. Greenberg
通讯作者：
D. Jamieson;J. Greenberg
影响因子：
10.6
作者：
Zhang Xiangsong;Shi Xingchong;Chen Zhifeng
通讯作者：
Chen Zhifeng