Reverberant magnetic resonance elastographic imaging using a single mechanical driver.
Reverberant magnetic resonance elastographic imaging using a single mechanical driver.
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DOI：
10.1088/1361-6560/acbbb7
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发表时间：
2023-02-27
影响因子：
3.5
通讯作者：
中科院分区：
文献类型：
--
作者：
反射弹性成像提供了剪切模量的快速和可靠的估计;然而，其对多个机械驱动器的依赖阻碍了临床实用性。在这项工作中，我们假设，对于受约束的器官，如大脑，混响弹性成像可以产生准确的磁共振弹性图与一个单一的机械驱动器。为了证实这一假设，我们对健康志愿者（n = 3）进行了研究;和一个受约束的校准的脑体模含有直径范围为4-18 mm的球形夹杂物。在这两项研究（即体模和临床）中，成像在50和70 Hz的频率下进行。我们使用的准确性和对比度噪声比性能指标来评估混响弹性图相对于那些使用已建立的分区反演方法计算。当在50 Hz和3.1%和16.8%成像时，在混响弹性成像引起的误差变化从1.3%到16.6%。相比之下，分区弹性图中产生的误差范围为1.9%至13%，在50 Hz和3.6%至14.9%，在70 Hz。混响弹性图的对比度噪声比范围为63.1至73 dB，而分区弹性图为65至66.2 dB。在50 Hz和70 Hz时，由混响和分区弹性图估计的平均整体脑剪切模量分别为2.36 ± 0.07 kPa和2.38 ± 0.11 kPa，分别为2.70 ± 0.20 kPa和2.89 ± 0.60 kPa。这项研究的结果表明，混响弹性成像可以产生准确的，高质量的弹性图的大脑与一个单一的机械驱动器。
Reverberant elastography provides fast and robust estimates of shear modulus; however, its reliance on multiple mechanical drivers hampers clinical utility. In this work, we hypothesize that for constrained organs such as the brain, reverberant elastography can produce accurate magnetic resonance elastograms with a single mechanical driver. To corroborate this hypothesis, we performed studies on healthy volunteers (n = 3); and a constrained calibrated brain phantom containing spherical inclusions with diameters ranging from 4–18 mm. In both studies (i.e. phantom and clinical), imaging was performed at frequencies of 50 and 70 Hz. We used the accuracy and contrast-to-noise ratio performance metrics to evaluate reverberant elastograms relative to those computed using the established subzone inversion method. Errors incurred in reverberant elastograms varied from 1.3% to 16.6% when imaging at 50 Hz and 3.1% and 16.8% when imaging at 70 Hz. In contrast, errors incurred in subzone elastograms ranged from 1.9% to 13% at 50 Hz and 3.6% to 14.9% at 70 Hz. The contrast-to-noise ratio of reverberant elastograms ranged from 63.1 to 73 dB compared to 65 to 66.2 dB for subzone elastograms. The average global brain shear modulus estimated from reverberant and subzone elastograms was 2.36 ± 0.07 kPa and 2.38 ± 0.11 kPa, respectively, when imaging at 50 Hz and 2.70 ± 0.20 kPa and 2.89 ± 0.60 kPa respectively, when imaging at 70 Hz. The results of this investigation demonstrate that reverberant elastography can produce accurate, high-quality elastograms of the brain with a single mechanical driver.
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影响因子：
19.7
作者：
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通讯作者：
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DOI：
10.1016/j.jmbbm.2016.03.005
发表时间：
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作者：
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