CMOS 256-Pixel/480-Pixel Photovoltaic-Powered Subretinal Prosthetic Chips With Wide Image Dynamic Range and Bi/Four-Directional Sharing Electrodes and Their Ex Vivo Experimental Validations With Mice
CMOS 256-Pixel/480-Pixel Photovoltaic-Powered Subretinal Prosthetic Chips With Wide Image Dynamic Range and Bi/Four-Directional Sharing Electrodes and Their Ex Vivo Experimental Validations With Mice
复制标题
具有宽图像动态范围和双向/四向共享电极的 CMOS 256 像素/480 像素光伏驱动视网膜下假体芯片及其小鼠离体实验验证
DOI：
10.1109/tcsi.2020.2976716
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Noda Toshihiko
中科院分区：
文献类型：
--
作者：
Wu Chung-Yu;Tseng Chi-Kuan;Liao Jung-Hsing;Chiao Chuan-Chin;Chu Fang-Liang;Tsai Yueh-Chun;Ohta Jun;Noda Toshihiko
针对视网膜下假体，提出并采用CIS工艺制作了基于光伏供电的256像素/480像素宽动态范围共用电极的CMOS光伏可植入芯片。红外(IR)光只入射到芯片的光伏电池上，而可见光主要入射到像素上。采用自适应背景抵消电路(ABCC)来增加图像的动态范围，使视网膜下芯片能够适应不同的环境照度。提出了一种用于电串扰模拟的二维等效电极模型，以分析串扰电荷，并使两个芯片的激励图案设计具有最小的串扰。此外，在256像素芯片中使用了双向共享电极(BDSE)，在相同的芯片面积下增加了电极尺寸，并将刺激电荷提高到11.4nC。采用四向共享电极(FDSE)在垂直和水平两个方向上共享电极，在相同的像素阵列面积下获得480个电极尺寸几乎相同的像素。最大刺激药量为9.8nC。在制作的256像素(480像素)芯片中，图像光的动态范围增加到31.65分贝(24.9分贝)。该芯片的功能已通过电测量和小鼠视网膜的体外膜片钳实验成功验证。
CMOS photovoltaic-powered 256-pixel/480-pixel implantable chips with a wide image dynamic range and shared electrodes are proposed and fabricated in CIS technology for subretinal prostheses. The infra-red (IR) light is incident only on photovoltaic cells of the chip whereas the visible light is mainly incident on pixels. The proposed adaptive background cancellation circuit (ABCC) is adopted to increase the image dynamic range so that the subretinal chips can adapt for different surrounding illuminances. A two-dimensional equivalent electrode model for electric crosstalk simulation is proposed to analyze the crosstalk charges and enable the stimulation pattern design with minimum crosstalk for both chips. Moreover, the bi-directional sharing electrodes (BDSEs) are used in the 256-pixel chip to increase electrode size under the same chip area and boost the stimulation charges to 11.4 nC. The four-directional sharing electrodes (FDSEs) are used to share the electrodes in both vertical and horizontal directions and achieve 480 pixels with nearly the same electrode size under the same pixel array area. The maximum stimulation charge is 9.8 nC. The dynamic range of image light is increased to 31.65 dB (24.9 dB) in the fabricated 256-pixel (480-pixel) chip. The functions of the chip have been successfully validated by both electrical measurement and ex vivo patch clamp experiments with the retinas of mice.
登录
查看更多内容
用于眼内视网膜前神经刺激器的植入电子设备
DOI：
--
发表时间：
2008
期刊：
2008 IEEE International Symposium on Circuits and Systems
影响因子：
--
作者：
T. Lehmann;N. Lovell;G. Suaning;P. Preston;Y. Wong;N. Dommel;L. H. Jung;Y. Moghe;K. Das
通讯作者：
K. Das
DOI：
10.1109/iembs.2008.4650530
发表时间：
2008
期刊：
2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
影响因子：
--
作者：
Wilfried Mokwa;M. Goertz;C. Koch;I. Krisch;H. Trieu;Peter Walter
通讯作者：
Peter Walter
用于视网膜前假体的 37.6mm2 1024 通道高顺应电压 SoC
DOI：
10.1109/isscc.2013.6487741
发表时间：
2013
期刊：
2013 IEEE International Solid-State Circuits Conference Digest of Technical Papers
影响因子：
--
作者：
Kuanfu Chen;Y. Lo;Wentai Liu
通讯作者：
Wentai Liu
用于视网膜假体的 0.8V 4096 像素 CMOS 传感和刺激成像器
影响因子：
3.1
作者：
Chih;C. Hsieh
通讯作者：
C. Hsieh
基于 CMOS 的智能电极型视网膜刺激器，具有子弹形散装 Pt 电极
DOI：
10.1109/iembs.2011.6091661
发表时间：
2011
期刊：
2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society
影响因子：
--
作者：
T. Tokuda;Takasuke Ito;Takuya Kitao;T. Noda;K. Sasagawa;Y. Terasawa;H. Tashiro;H. Kanda;T. Fujikado;J. Ohta
通讯作者：
J. Ohta