Crosstalk between epitranscriptomic and epigenetic mechanisms in gene regulation.
Crosstalk between epitranscriptomic and epigenetic mechanisms in gene regulation.
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DOI：
10.1016/j.tig.2021.06.014
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发表时间：
2022-03
影响因子：
11.4
通讯作者：
Sallam, Tamer
中科院分区：
文献类型：
--
作者：
Kan, Ryan L.;Chen, Jianjun;Sallam, Tamer
表观遗传修饰发生在基因组DNA和组蛋白上以影响基因表达。最近，发现mRNA经历了类似的化学修饰，强烈影响转录物的周转和翻译，增加了另一层动态基因调控。基因表达的精确和同步调节的核心是转录物生物合成和加工中涉及的多个检查点之间的复杂串扰。在哺乳动物细胞中有超过100种RNA的内部修饰。最常见的是N6-甲基腺苷（m6 A）甲基化。虽然m6 A被确立为影响RNA稳定性动力学和翻译效率，但迅速积累的证据显示RNA甲基化和组蛋白/DNA表观遗传机制之间存在显著的串扰。这些相互作用指定转录输出、翻译、染色质修饰剂的募集以及m6 A甲基转移酶复合物（MTC）在靶位点的部署。在这篇综述中，我们剖析了m6 A精心策划的反馈回路，这些回路调节组蛋白修饰和调节RNA（例如长非编码（lnc）RNA和染色体相关调节RNA）的活性。总的来说，这些证据表明，m6 A作为一个多功能的检查点，可以将不同层次的基因调控相互耦合。
Epigenetic modifications occur on genomic DNA and histones to influence gene expression. More recently, the discovery that mRNA undergoes similar chemical modifications that powerfully impact transcript turnover and translation adds another layer of dynamic gene regulation. Central to precise and synchronized regulation of gene expression is intricate crosstalk between multiple checkpoints involved in transcript biosynthesis and processing. There are more than 100 internal modifications of RNA in mammalian cells. The most common is N6-methyladenosine (m6A) methylation. Although m6A is established to influence RNA stability dynamics and translation efficiency, rapidly accumulating evidence shows significant crosstalk between RNA methylation and histone/DNA epigenetic mechanisms. These interactions specify transcriptional outputs, translation, recruitment of chromatin modifiers, as well as the deployment of the m6A methyltransferase complex (MTC) at target sites. In this review, we dissect m6A-orchestrated feedback circuits that regulate histone modifications and the activity of regulatory RNAs, such as long noncoding (lnc)RNA and chromosome-associated regulatory RNA. Collectively, this body of evidence suggests that m6A acts as a versatile checkpoint that can couple different layers of gene regulation with one another.
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DOI：
10.1038/s41576-019-0135-1
发表时间：
2019-09
期刊：
Nature reviews. Genetics
影响因子：
--
作者：
Li X;Fu XD
通讯作者：
Fu XD
影响因子：
48
作者：
Linder, Bastian;Grozhik, Anya V.;Olarerin-George, Anthony O.;Meydan, Cem;Mason, Christopher E.;Jaffrey, Samie R.
通讯作者：
Jaffrey, Samie R.
影响因子：
10.5
作者：
Ke S;Alemu EA;Mertens C;Gantman EC;Fak JJ;Mele A;Haripal B;Zucker-Scharff I;Moore MJ;Park CY;Vågbø CB;Kusśnierczyk A;Klungland A;Darnell JE Jr;Darnell RB
通讯作者：
Darnell RB
赖氨酸 36 处的组蛋白 H3 三甲基化引导 m(6)A RNA 共转录修饰
影响因子：
64.8
作者：
Huang, Huilin;Weng, Hengyou;Chen, Jianjun
通讯作者：
Chen, Jianjun
影响因子：
5.6
作者：
GREENBERG, H;PENMAN, S
通讯作者：
PENMAN, S