Modulation of neuronal excitability by binge alcohol drinking.

Modulation of neuronal excitability by binge alcohol drinking.
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DOI:
10.3389/fnmol.2023.1098211
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发表时间:
2023
影响因子:
4.8
通讯作者:
Martin, Gilles E.
Martin, Gilles E.
中科院分区:
医学2区
文献类型:
--
作者:
Gimenez-Gomez, Pablo;Le, Timmy;Martin, Gilles E.

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Drug use poses a serious threat to health systems throughout the world. The number of consumers rises every year being alcohol the drug of abuse most consumed causing 3 million deaths (5.3% of all deaths) worldwide and 132.6 million disability-adjusted life years. In this review, we present an up-to-date summary about what is known regarding the global impact of binge alcohol drinking on brains and how it affects the development of cognitive functions, as well as the various preclinical models used to probe its effects on the neurobiology of the brain. This will be followed by a detailed report on the state of our current knowledge of the molecular and cellular mechanisms underlying the effects of binge drinking on neuronal excitability and synaptic plasticity, with an emphasis on brain regions of the meso-cortico limbic neurocircuitry.
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