Double-blind comparison of bromocriptine and placebo in cocaine withdrawal.
Double-blind comparison of bromocriptine and placebo in cocaine withdrawal.
复制标题
溴隐亭和安慰剂在可卡因戒断中的双盲比较。
DOI：
--
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Rebecca Lowery
中科院分区：
文献类型：
--
作者：
Kathryn Eiler;M. Schaefer;Daniel Salstrom;Rebecca Lowery
29 名没有其他药物依赖的可卡因依赖男性退伍军人完成了一项双盲对照、随机分配的研究，检验溴隐亭与安慰剂在治疗可卡因戒断症状方面的功效。在研究完成之前和之后获得血清催乳素（PL）和生长激素（GH）水平。患者每天都会接受检查并完成几份自我报告调查问卷，包括症状检查表 90 修订版、贝克抑郁量表和可卡因渴望报告。患者还被要求评价各种可卡因戒断症状。总体而言，在停止使用可卡因后的前 3 周内，与安慰剂相比，接受溴隐亭似乎没有任何优势，但活动和食欲水平的变化可能除外。安慰剂组在治疗的第一周内表现出统计上显着的活动水平增加，并且在整个研究过程中食欲显着增加。两组患者在其他评估领域均表现出显着改善，并且改善似乎根据治疗时间的长短而进展。该患者样本中未发现高催乳素血症或异常 GH 水平。最初的 63 名患者中有 34 名退出了研究。 17 人接受溴隐亭治疗，17 人接受安慰剂治疗。药物组之间保留患者接受治疗的发生率没有显着差异。高退出率可能反映了让可卡因依赖患者继续接受治疗所面临的困难。
Twenty-nine cocaine-dependent male veterans without other drug dependence completed a double-blind controlled, randomly-assigned study examining the efficacy of bromocriptine versus placebo in the management of cocaine abstinence symptomatology. Serum prolactin (PL) and growth hormone (GH) levels were obtained prior to and after the study was completed. Patients were seen daily and completed several self-report questionnaires, including the Symptom Checklist-90-Revised, the Beck Depression Inventory, and a Cocaine Craving Report. The patients were also asked to rate a variety of cocaine withdrawal symptoms. Overall, there did not appear to be any advantage to receiving bromocriptine versus placebo during the first 3 weeks following cocaine use cessation with the possible exception of changes in activity and appetite level. The placebo group showed a statistically significant increase in activity level during the first week in treatment and a significant increase in appetite throughout the study. Patients in both groups showed significant improvement in the other areas assessed, with improvement appearing to progress according to length of treatment. Hyperprolactinemia or abnormal GH levels were not found in this patient sample as a group. Thirty-four of the original 63 patients dropped out of the study. Seventeen received bromocriptine, and 17 received placebo. There was no significant difference between drug groups in incidence of retaining patients in treatment. The high dropout rate may reflect the difficulty incurred in retaining cocaine-dependent patients in treatment.
可卡因戒断期间的垂体前叶、肾上腺和性腺激素。
DOI：
10.1176/ajp.145.9.1094
发表时间：
1988
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Mendelson,JH;Teoh,SK;Lange,U;Mello,NK;Weiss,R;Skupny,A;Ellingboe,J
通讯作者：
Ellingboe,J
影响因子：
56.9
作者：
GOEDERS, NE;SMITH, JE
通讯作者：
SMITH, JE