Computational Investigation of Transmural Differences in Left Ventricular Contractility.
Computational Investigation of Transmural Differences in Left Ventricular Contractility.
复制标题
左心室收缩力跨壁差异的计算研究。
DOI：
10.1115/1.4034558
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Wenk,JonathanF
中科院分区：
文献类型：
--
作者：
Wang,Hua;Zhang,Xiaoyan;Dorsey,ShaunaM;McGarvey,JeremyR;Campbell,KennethS;Burdick,JasonA;Gorman3rd,JosephH;Pilla,JamesJ;Gorman,RobertC;Wenk,JonathanF
Myocardial contractility of the left ventricle (LV) plays an essential role in maintaining normal pump function. A recent ex vivo experimental study showed that cardiomyocyte force generation varies across the three myocardial layers of the LV wall. However, the in vivo distribution of myocardial contractile force is still unclear. The current study was designed to investigate the in vivo transmural distribution of myocardial contractility using a noninvasive computational approach. For this purpose, four cases with different transmural distributions of maximum isometric tension (Tmax) and/or reference sarcomere length (lR) were tested with animal-specific finite element (FE) models, in combination with magnetic resonance imaging (MRI), pressure catheterization, and numerical optimization. Results of the current study showed that the best fit with in vivo MRI-derived deformation was obtained when Tmaxassumed different values in the subendocardium, midmyocardium, and subepicardium with transmurally varying lR. These results are consistent with recent ex vivo experimental studies, which showed that the midmyocardium produces more contractile force than the other transmural layers. The systolic strain calculated from the best-fit FE model was in good agreement with MRI data. Therefore, the proposed noninvasive approach has the capability to predict the transmural distribution of myocardial contractility. Moreover, FE models with a nonuniform distribution of myocardial contractility could provide a better representation of LV function and be used to investigate the effects of transmural changes due to heart disease.
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DOI：
10.1115/1.4003438
发表时间：
2011-04
期刊：
Journal of biomechanical engineering
影响因子：
--
作者：
Wenk JF;Sun K;Zhang Z;Soleimani M;Ge L;Saloner D;Wallace AW;Ratcliffe MB;Guccione JM
通讯作者：
Guccione JM
DOI：
10.1016/j.athoracsur.2015.03.015
发表时间：
2015-08
期刊：
The Annals of thoracic surgery
影响因子：
--
作者：
McGarvey JR;Mojsejenko D;Dorsey SM;Nikou A;Burdick JA;Gorman JH 3rd;Jackson BM;Pilla JJ;Gorman RC;Wenk JF
通讯作者：
Wenk JF
影响因子：
--
作者：
RODRIGUEZ, EK;OMENS, JH;MCCULLOCH, AD
通讯作者：
MCCULLOCH, AD
DOI：
10.1115/1.2895474
发表时间：
1993-02-01
影响因子：
1.7
作者：
GUCCIONE, JM;WALDMAN, LK;MCCULLOCH, AD
通讯作者：
MCCULLOCH, AD
影响因子：
10.8
作者：
van der Velden, J;Klein, LJ;Stienen, GJM
通讯作者：
Stienen, GJM