Nucleus accumbens shell and core involvement in drug context-induced reinstatement of cocaine seeking in rats.
Nucleus accumbens shell and core involvement in drug context-induced reinstatement of cocaine seeking in rats.
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DOI：
10.1007/s00213-008-1234-4
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发表时间：
2008-11
影响因子：
3.4
通讯作者：
Bell, Guinevere H.
中科院分区：
文献类型：
--
作者：
Fuchs, Rita A.;Ramirez, Donna R.;Bell, Guinevere H.
在药物复吸动物模型中，伏隔核（NAC）参与由药物相关的外显条件刺激、足部休克应激或可卡因本身引发的可卡因寻求行为，是一个功能异质的脑区。然而，尚不清楚NAC或其分区域是否对因重新暴露于以前的可卡因配对环境背景而产生的可卡因寻求行为的恢复至关重要。本研究旨在评估NAC核和壳对这种行为的潜在独特贡献。在不同的环境背景下，大鼠被训练为杠杆按压无信号可卡因输注（0.15 mg/输注，静脉注射）。然后在至少七次的日常训练中，杠杆反应在明显不同的环境背景下（灭绝背景）消失。随后，使用平衡测试设计，大鼠再次暴露于可卡因配对环境或灭绝环境中，同时评估可卡因寻求（即对先前可卡因增强杠杆的反应）。每次试验前，双侧微滴注γ-氨基丁酸激动剂、巴氯芬和muscimol（0/0或1.0/0.1 mM，每半球0.3 μl）选择性抑制NAC核或壳的神经活动。NAC外壳或核心的神经失活在可卡因环境中减弱了反应，有趣的是，在消失环境中增加了反应。对照实验表明，对一般活动或食物强化的工具行为没有影响。这些发现表明，NAC的两个亚区都可能通过促进毒品情境诱导的可卡因动机和情境歧视来促进情境诱导的恢复。
The nucleus accumbens (NAC) is a functionally heterogeneous brain region with respect to its involvement in cocaine-seeking behavior triggered by drug-associated explicit conditioned stimuli, foot shock stress, or cocaine itself in the reinstatement animal model of drug relapse. However, it is not known whether the NAC or its subregions are critical for reinstatement of cocaine-seeking behavior produced by re-exposure to a previously cocaine-paired environmental context. The present study was designed to evaluate potentially unique contributions of the NAC core and shell to this behavior. Rats were trained to lever press for unsignaled cocaine infusions (0.15 mg/infusion, intravenous) in a distinct environmental context. Lever responding was then extinguished in a distinctly different environmental context (extinction context) during a minimum of seven daily training sessions. Subsequently, using a counterbalanced testing design, rats were re-exposed to the cocaine-paired context or the extinction context while cocaine seeking (i.e., responding on the previously cocaine-reinforced lever) was assessed. Before each test session, neural activity was inhibited selectively in the NAC core or shell using bilateral microinfusions of the γ-aminobutyric acid agonists, baclofen and muscimol (0/0 or 1.0/0.1 mM; 0.3 μl per hemisphere). Neural inactivation of the NAC shell or core attenuated responding in the cocaine context and, interestingly, increased responding in the extinction context. Control experiments indicated no effects on general activity or food-reinforced instrumental behavior. These findings suggest that both subregions of the NAC may promote context-induced reinstatement by facilitating drug context-induced motivation for cocaine and context discrimination.
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影响因子：
3.3
作者：
EVERITT, BJ;MORRIS, KA;ROBBINS, TW
通讯作者：
ROBBINS, TW
影响因子：
3.4
作者：
Fuchs, RA;Tran-Nguyen, LTL;Neisewander, JL
通讯作者：
Neisewander, JL
影响因子：
5.3
作者：
Di Ciano, P;Cardinal, RN;Everitt, BJ
通讯作者：
Everitt, BJ
DOI：
10.1073/pnas.98.4.1976
发表时间：
2001-02-13
影响因子：
11.1
作者：
Ciccocioppo, R;Sanna, PP;Weiss, F
通讯作者：
Weiss, F
影响因子：
3.4
作者：
Fuchs, RA;See, RE
通讯作者：
See, RE