Development of the hippocampal cognitive map in preweanling rats.
Development of the hippocampal cognitive map in preweanling rats.
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DOI:
10.1126/science.1188224
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发表时间:
2010-06-18
期刊:
影响因子:
--
通讯作者:
O'Keefe J
中科院分区:
文献类型:
--
作者:
Wills TJ;Cacucci F;Burgess N;O'Keefe J
Orienting in large-scale space depends on the interaction of environmental experience and pre-configured, possibly innate, constructs. Place, head-direction and grid cells in the hippocampal formation provide allocentric representations of space. Here we show how these cognitive representations emerge and develop as rat pups first begin to explore their environment. Directional, locational and rhythmic organization of firing are present during initial exploration, including adult-like directional firing. The stability and precision of place cell firing continues to develop throughout juvenility. Stable grid cell firing appears later but matures rapidly to adult levels. Our results demonstrate the presence of three neuronal representations of space prior to extensive experience, and show how they develop with age.
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影响因子:
64.8
作者:
HERMER, L;SPELKE, ES
通讯作者:
SPELKE, ES
影响因子:
1.9
作者:
RUDY, JW;STADLERMORRIS, S;ALBERT, P
通讯作者:
ALBERT, P
影响因子:
56.9
作者:
Solstad, Trygve;Boccara, Charlotte N.;Moser, Edvard I.
通讯作者:
Moser, Edvard I.
影响因子:
2.5
作者:
Burton, Brian G.;Economo, Michael N.;White, John A.
通讯作者:
White, John A.
DOI:
10.1016/s0163-1047(85)91510-9
发表时间:
1985-01-01
期刊:
BEHAVIORAL AND NEURAL BIOLOGY
影响因子:
--
作者:
SCHENK, F
通讯作者:
SCHENK, F