Development of the hippocampal cognitive map in preweanling rats.

Development of the hippocampal cognitive map in preweanling rats.
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DOI:
10.1126/science.1188224
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发表时间:
2010-06-18
期刊:
Science (New York, N.Y.)
影响因子:
--
通讯作者:
O'Keefe J
O'Keefe J
中科院分区:
其他
文献类型:
--
作者:
Wills TJ;Cacucci F;Burgess N;O'Keefe J

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大规模空间的定位取决于环境体验和预配置(可能是天生的)构造的相互作用。海马结构中的位置、头部方向和网格细胞提供了空间的异中心表征。在这里,我们展示了这些认知表征是如何出现和发展的大鼠幼崽第一次开始探索他们的环境。在最初的探索过程中,存在方向性、位置性和节律性的放电组织,包括成人样的定向放电。位置细胞放电的稳定性和精确性在整个青少年时期继续发展。稳定的网格细胞放电出现较晚,但迅速成熟到成人水平。我们的研究结果表明,在广泛的经验之前,存在三种神经元的空间表征,并显示它们如何随着年龄的增长而发展。
Orienting in large-scale space depends on the interaction of environmental experience and pre-configured, possibly innate, constructs. Place, head-direction and grid cells in the hippocampal formation provide allocentric representations of space. Here we show how these cognitive representations emerge and develop as rat pups first begin to explore their environment. Directional, locational and rhythmic organization of firing are present during initial exploration, including adult-like directional firing. The stability and precision of place cell firing continues to develop throughout juvenility. Stable grid cell firing appears later but matures rapidly to adult levels. Our results demonstrate the presence of three neuronal representations of space prior to extensive experience, and show how they develop with age.
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发表时间: 1994-07-07
期刊: NATURE
影响因子: 64.8
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