RON Mediates Tumor-Promoting Effects in Endometrial Adenocarcinoma.
RON Mediates Tumor-Promoting Effects in Endometrial Adenocarcinoma.
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RON 介导子宫内膜腺癌的促肿瘤作用
DOI：
10.1155/2021/2282916
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发表时间：
2021
影响因子：
--
通讯作者：
Zhang X
中科院分区：
文献类型：
--
作者：
Yu Q;Wang J;Li T;Xu X;Guo X;Ding S;Zhu L;Zou G;Chen Y;Zhang X
子宫内膜腺癌是世界上最常见的女性生殖道癌之一，开发有效的治疗方法仍是其目前研究的主要目标。上皮-间充质转化(EMT)在包括子宫内膜腺癌在内的上皮性癌的发生发展中起重要作用。在多种上皮源性肿瘤中，RON可诱导EMT并促进其增殖、迁移和侵袭，但其在子宫内膜腺癌中的作用尚不清楚。本研究的目的是验证RON在子宫内膜腺癌中的过度表达，并探讨其在子宫内膜腺癌中的作用。用免疫组织化学方法检测肿瘤组织中RON的表达，用HEC-1B细胞构建RON过表达或基因敲除的稳定细胞系，观察RON对子宫内膜腺癌细胞功能的影响，并进行裸鼠异种移植实验，探讨RON对子宫内膜腺癌细胞生长的影响。本研究表明，RON可促进HEC-1B细胞的增殖、迁移和侵袭，并诱导EMT，这些作用是通过Smad途径调节的。RON过表达可促进子宫内膜腺癌细胞在裸鼠体内的生长，其抑制物BMS777607可抑制该作用。RON在子宫内膜腺癌中发挥重要作用，有可能成为治疗子宫内膜腺癌的新靶点。
Endometrial adenocarcinoma is one of the most prevalent female reproductive tract cancers in the world, and the development of effective treatment is still the main goal of its current research. Epithelial-mesenchymal transition (EMT) plays a significant part in the occurrence and development of epithelial carcinoma, including endometrial adenocarcinoma. Recepteur d'origine nantais (RON) induces EMT and promotes proliferation, migration, and invasion in various epithelial-derived cancers, but its role in endometrial adenocarcinoma is still poorly studied. The purpose of this study is to verify the overexpression of RON in endometrial adenocarcinoma and to explore its specific roles. RON expression in tumor lesions was verified by immunohistochemical staining, HEC-1B cells were used to construct stable cell lines with RON overexpression or knockdown to investigate the effects of RON on the function of endometrial adenocarcinoma cells, and xenotransplantation experiment was carried out in nude mice to explore the effect of RON on the growth of endometrial adenocarcinoma in vivo. This study revealed that RON could promote the proliferation, migration, and invasion of HEC-1B cells and induce EMT, and these effects were regulated through the Smad pathway. RON overexpression could promote growth of endometrial adenocarcinoma cells in nude mice, while its inhibitor BMS777607 could restrict this role. RON played an important role in endometrial adenocarcinoma and had a potential to become a new therapeutic target for endometrial adenocarcinoma.
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影响因子：
9.7
作者：
Bourn JR;Ruiz-Torres SJ;Hunt BG;Benight NM;Waltz SE
通讯作者：
Waltz SE
子宫内膜异位症女性卵巢子宫内膜异位病变中色素上皮衍生因子表达减少和微血管密度增加。
DOI：
10.1016/j.ejogrb.2012.06.034
发表时间：
2012-11-01
影响因子：
2.6
作者：
Huang, Xiufeng;Chen, Liqing;Zhang, Xinmei
通讯作者：
Zhang, Xinmei
影响因子：
37.3
作者：
Ma Q;Guin S;Padhye SS;Zhou YQ;Zhang RW;Wang MH
通讯作者：
Wang MH
影响因子：
4.7
作者：
SAKURAGI, N;NISHIYA, M;FUJIMOTO, S
通讯作者：
FUJIMOTO, S
影响因子：
5.2
作者：
Kim, Sun-Ae;Lee, Kyung-Hwa;Yoon, Tae Mi
通讯作者：
Yoon, Tae Mi